| Anti-inflammatory evaluation and structure-activity relationships of diterpenoids isolated from Euphorbia hylonoma | |
Wei, Wen-Jun1; Qi, Weiyan2; Gao, Xin-Mei2; Feng, Ke-Na3,4 ; Ma, Kai-Liang1; Li, Hang-Ying1; Li, Ya1; Gao, Kun1
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| Corresponding Author | Li, Ya(liea@lzu.edu.cn) ; Gao, Kun(npchem@lzu.edu.cn) |
| 2019-12-01 | |
| Source Publication | BIOORGANIC CHEMISTRY
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| ISSN | 0045-2068 |
| Volume | 93Pages:10 |
| Abstract | A phytochemical investigation to obtain chemical components with potential anti-inflammatory activity from E. hylonoma led to the isolation of nine new ent-isopimarane diterpenoids (1 and 3-10), a new ent-rosane diterpenoid (11), along with eight known ones (2 and 12-18) using various chromatographic techniques. Compounds 3, 4, 5, and 10 were rare examples of the epoxy-ent-isopimarane. The structures of these new compounds were confirmed by extensive spectroscopic data, crystal X-ray diffraction analysis, and electronic circular dichroism. And the isolates were evaluated for their inhibitory effects on nitric oxide production induced by lipopolysaccharide in RAW 264.7 cells. The results showed that compounds 2 and 12 exhibited noteworthy inhibitory effects against NO production with IC50 values of 7.12 and 12.73 mu M, respectively, which were better than positive control (IC50 = 41.41 mu M). The possible mechanism that compounds 2 and 12 could inhibit NO production was investigated by the Western blotting experiments. |
| Keyword | Euphorbia hylonoma ent-Isopimarane ent-Rosane Anti-inflammatory |
| DOI | 10.1016/j.bioorg.2019.103256 |
| Indexed By | SCI ; SCI |
| Language | 英语 |
| WOS ID | WOS:000499717000017 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/70694 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Li, Ya; Gao, Kun |
| Affiliation | 1.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China 2.China Pharmaceut Univ, Sch Life Sci & Technol, Dept Marine Pharm, Nanjing 211198, Jiangsu, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China |
| Recommended Citation GB/T 7714 | Wei, Wen-Jun,Qi, Weiyan,Gao, Xin-Mei,et al. Anti-inflammatory evaluation and structure-activity relationships of diterpenoids isolated from Euphorbia hylonoma[J]. BIOORGANIC CHEMISTRY,2019,93:10. |
| APA | Wei, Wen-Jun.,Qi, Weiyan.,Gao, Xin-Mei.,Feng, Ke-Na.,Ma, Kai-Liang.,...&Gao, Kun.(2019).Anti-inflammatory evaluation and structure-activity relationships of diterpenoids isolated from Euphorbia hylonoma.BIOORGANIC CHEMISTRY,93,10. |
| MLA | Wei, Wen-Jun,et al."Anti-inflammatory evaluation and structure-activity relationships of diterpenoids isolated from Euphorbia hylonoma".BIOORGANIC CHEMISTRY 93(2019):10. |
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| Wei-2019-Anti-inflam（2502KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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