Anti-inflammatory evaluation and structure-activity relationships of diterpenoids isolated from Euphorbia hylonoma
Wei, Wen-Jun1; Qi, Weiyan2; Gao, Xin-Mei2; Feng, Ke-Na3,4; Ma, Kai-Liang1; Li, Hang-Ying1; Li, Ya1; Gao, Kun1
Corresponding AuthorLi, Ya(liea@lzu.edu.cn) ; Gao, Kun(npchem@lzu.edu.cn)
2019-12-01
Source PublicationBIOORGANIC CHEMISTRY
ISSN0045-2068
Volume93Pages:10
AbstractA phytochemical investigation to obtain chemical components with potential anti-inflammatory activity from E. hylonoma led to the isolation of nine new ent-isopimarane diterpenoids (1 and 3-10), a new ent-rosane diterpenoid (11), along with eight known ones (2 and 12-18) using various chromatographic techniques. Compounds 3, 4, 5, and 10 were rare examples of the epoxy-ent-isopimarane. The structures of these new compounds were confirmed by extensive spectroscopic data, crystal X-ray diffraction analysis, and electronic circular dichroism. And the isolates were evaluated for their inhibitory effects on nitric oxide production induced by lipopolysaccharide in RAW 264.7 cells. The results showed that compounds 2 and 12 exhibited noteworthy inhibitory effects against NO production with IC50 values of 7.12 and 12.73 mu M, respectively, which were better than positive control (IC50 = 41.41 mu M). The possible mechanism that compounds 2 and 12 could inhibit NO production was investigated by the Western blotting experiments.
KeywordEuphorbia hylonoma ent-Isopimarane ent-Rosane Anti-inflammatory
DOI10.1016/j.bioorg.2019.103256
Indexed BySCI ; SCI
Language英语
WOS IDWOS:000499717000017
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/70694
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLi, Ya; Gao, Kun
Affiliation1.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
2.China Pharmaceut Univ, Sch Life Sci & Technol, Dept Marine Pharm, Nanjing 211198, Jiangsu, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Wei, Wen-Jun,Qi, Weiyan,Gao, Xin-Mei,et al. Anti-inflammatory evaluation and structure-activity relationships of diterpenoids isolated from Euphorbia hylonoma[J]. BIOORGANIC CHEMISTRY,2019,93:10.
APA Wei, Wen-Jun.,Qi, Weiyan.,Gao, Xin-Mei.,Feng, Ke-Na.,Ma, Kai-Liang.,...&Gao, Kun.(2019).Anti-inflammatory evaluation and structure-activity relationships of diterpenoids isolated from Euphorbia hylonoma.BIOORGANIC CHEMISTRY,93,10.
MLA Wei, Wen-Jun,et al."Anti-inflammatory evaluation and structure-activity relationships of diterpenoids isolated from Euphorbia hylonoma".BIOORGANIC CHEMISTRY 93(2019):10.
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