| Anti-inflammatory evaluation and structure-activity relationships of diterpenoids isolated from Euphorbia hylonoma | |
Wei, Wen-Jun1; Qi, Weiyan2; Gao, Xin-Mei2; Feng, Ke-Na3,4 ; Ma, Kai-Liang1; Li, Hang-Ying1; Li, Ya1; Gao, Kun1
| |
| 通讯作者 | Li, Ya(liea@lzu.edu.cn) ; Gao, Kun(npchem@lzu.edu.cn) |
| 2019-12-01 | |
| 发表期刊 | BIOORGANIC CHEMISTRY
 |
| ISSN | 0045-2068 |
| 卷号 | 93页码:10 |
| 摘要 | A phytochemical investigation to obtain chemical components with potential anti-inflammatory activity from E. hylonoma led to the isolation of nine new ent-isopimarane diterpenoids (1 and 3-10), a new ent-rosane diterpenoid (11), along with eight known ones (2 and 12-18) using various chromatographic techniques. Compounds 3, 4, 5, and 10 were rare examples of the epoxy-ent-isopimarane. The structures of these new compounds were confirmed by extensive spectroscopic data, crystal X-ray diffraction analysis, and electronic circular dichroism. And the isolates were evaluated for their inhibitory effects on nitric oxide production induced by lipopolysaccharide in RAW 264.7 cells. The results showed that compounds 2 and 12 exhibited noteworthy inhibitory effects against NO production with IC50 values of 7.12 and 12.73 mu M, respectively, which were better than positive control (IC50 = 41.41 mu M). The possible mechanism that compounds 2 and 12 could inhibit NO production was investigated by the Western blotting experiments. |
| 关键词 | Euphorbia hylonoma ent-Isopimarane ent-Rosane Anti-inflammatory |
| DOI | 10.1016/j.bioorg.2019.103256 |
| 收录类别 | SCI ; SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000499717000017 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/70694 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Li, Ya; Gao, Kun |
| 作者单位 | 1.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China 2.China Pharmaceut Univ, Sch Life Sci & Technol, Dept Marine Pharm, Nanjing 211198, Jiangsu, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Wen-Jun,Qi, Weiyan,Gao, Xin-Mei,et al. Anti-inflammatory evaluation and structure-activity relationships of diterpenoids isolated from Euphorbia hylonoma[J]. BIOORGANIC CHEMISTRY,2019,93:10. |
| APA | Wei, Wen-Jun.,Qi, Weiyan.,Gao, Xin-Mei.,Feng, Ke-Na.,Ma, Kai-Liang.,...&Gao, Kun.(2019).Anti-inflammatory evaluation and structure-activity relationships of diterpenoids isolated from Euphorbia hylonoma.BIOORGANIC CHEMISTRY,93,10. |
| MLA | Wei, Wen-Jun,et al."Anti-inflammatory evaluation and structure-activity relationships of diterpenoids isolated from Euphorbia hylonoma".BIOORGANIC CHEMISTRY 93(2019):10. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Wei-2019-Anti-inflam（2502KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论