| Kalshinoids A-F, Anti-inflammatory Sesquiterpenes from Kalimeris shimadae | |
| Wang, Guo-Kai1,2; Zhang, Nan1; Yao, Jian-Neng3; Yu, Yang3; Wang, Gang1; Hung, Chin-Chuan4; Cheng, Yung-Yi2,5; Morris-Natschke, Susan L.2; Zhou, Zhong-Yu6; Liu, Jin-Song1; Lee, Kuo-Hsiung2,5 | |
| 通讯作者 | Liu, Jin-Song(jinsongliu@ahtcm.edu.cn) ; Lee, Kuo-Hsiung(khlee@unc.edu) |
| 2019-12-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
 |
| ISSN | 0163-3864 |
| 卷号 | 82期号:12页码:3372-3378 |
| 摘要 | In a study of the potential anti-inflammatory constituents from Kalimeris shimadae, six new sesquiterpenes, kalshinoids A F (1-6), together with 21 known compounds (7-27), were isolated. The structures and absolute configurations of the new compounds were discerned from extensive spectroscopic analysis, and the absolute configurations of kalshinoids A, B, E, and F were established by ECD calculations. Furthermore, the identified compounds were tested for antiinflammatory activity as assessed by inhibition of tumor necrosis factor-alpha (TNF-alpha) in THP-1 cells. Three sesquiterpenes [kalshinoid F, 4(15)-eudesmen-1 beta,7,11-triol, and 4 alpha,10 alpha,11-trihydroxy-1 beta H,5 beta H-guai-7(8)-ene] reduced levels of TNF-alpha in lipopolysaccharide-stimulated THP-1 cells in a concentration dependent manner and were more potent than dexamethasone. These natural sesquiterpenes merit further investigation as possible anti-inflammatory agents. |
| DOI | 10.1021/acs.jnatprod.9b00693 |
| 收录类别 | SCI ; SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000505629000018 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/70544 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Liu, Jin-Song; Lee, Kuo-Hsiung |
| 作者单位 | 1.Anhui Univ Chinese Med, Sch Pharm, Anhui Key Lab Modern Chinese Mat Med, Hefei 230012, Anhui, Peoples R China 2.Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.China Med Univ, Dept Pharm, Coll Pharm, Taichung 40402, Taiwan 5.China Med Univ & Hosp, Chinese Med Res & Dev Ctr, Taichung 40402, Taiwan 6.Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Guo-Kai,Zhang, Nan,Yao, Jian-Neng,et al. Kalshinoids A-F, Anti-inflammatory Sesquiterpenes from Kalimeris shimadae[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(12):3372-3378. |
| APA | Wang, Guo-Kai.,Zhang, Nan.,Yao, Jian-Neng.,Yu, Yang.,Wang, Gang.,...&Lee, Kuo-Hsiung.(2019).Kalshinoids A-F, Anti-inflammatory Sesquiterpenes from Kalimeris shimadae.JOURNAL OF NATURAL PRODUCTS,82(12),3372-3378. |
| MLA | Wang, Guo-Kai,et al."Kalshinoids A-F, Anti-inflammatory Sesquiterpenes from Kalimeris shimadae".JOURNAL OF NATURAL PRODUCTS 82.12(2019):3372-3378. |
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