Kalshinoids A-F, Anti-inflammatory Sesquiterpenes from Kalimeris shimadae
Wang, Guo-Kai1,2; Zhang, Nan1; Yao, Jian-Neng3; Yu, Yang3; Wang, Gang1; Hung, Chin-Chuan4; Cheng, Yung-Yi2,5; Morris-Natschke, Susan L.2; Zhou, Zhong-Yu6; Liu, Jin-Song1; Lee, Kuo-Hsiung2,5
Corresponding AuthorLiu, Jin-Song(jinsongliu@ahtcm.edu.cn) ; Lee, Kuo-Hsiung(khlee@unc.edu)
AbstractIn a study of the potential anti-inflammatory constituents from Kalimeris shimadae, six new sesquiterpenes, kalshinoids A F (1-6), together with 21 known compounds (7-27), were isolated. The structures and absolute configurations of the new compounds were discerned from extensive spectroscopic analysis, and the absolute configurations of kalshinoids A, B, E, and F were established by ECD calculations. Furthermore, the identified compounds were tested for antiinflammatory activity as assessed by inhibition of tumor necrosis factor-alpha (TNF-alpha) in THP-1 cells. Three sesquiterpenes [kalshinoid F, 4(15)-eudesmen-1 beta,7,11-triol, and 4 alpha,10 alpha,11-trihydroxy-1 beta H,5 beta H-guai-7(8)-ene] reduced levels of TNF-alpha in lipopolysaccharide-stimulated THP-1 cells in a concentration dependent manner and were more potent than dexamethasone. These natural sesquiterpenes merit further investigation as possible anti-inflammatory agents.
Indexed BySCI ; SCI
WOS IDWOS:000505629000018
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Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorLiu, Jin-Song; Lee, Kuo-Hsiung
Affiliation1.Anhui Univ Chinese Med, Sch Pharm, Anhui Key Lab Modern Chinese Mat Med, Hefei 230012, Anhui, Peoples R China
2.Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
4.China Med Univ, Dept Pharm, Coll Pharm, Taichung 40402, Taiwan
5.China Med Univ & Hosp, Chinese Med Res & Dev Ctr, Taichung 40402, Taiwan
6.Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Peoples R China
Recommended Citation
GB/T 7714
Wang, Guo-Kai,Zhang, Nan,Yao, Jian-Neng,et al. Kalshinoids A-F, Anti-inflammatory Sesquiterpenes from Kalimeris shimadae[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(12):3372-3378.
APA Wang, Guo-Kai.,Zhang, Nan.,Yao, Jian-Neng.,Yu, Yang.,Wang, Gang.,...&Lee, Kuo-Hsiung.(2019).Kalshinoids A-F, Anti-inflammatory Sesquiterpenes from Kalimeris shimadae.JOURNAL OF NATURAL PRODUCTS,82(12),3372-3378.
MLA Wang, Guo-Kai,et al."Kalshinoids A-F, Anti-inflammatory Sesquiterpenes from Kalimeris shimadae".JOURNAL OF NATURAL PRODUCTS 82.12(2019):3372-3378.
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