Aromatization of natural products by a specialized detoxification enzyme
Huang, Jin-Quan1; Fang, Xin2; Tian, Xiu1; Chen, Ping1; Lin, Jia-Ling1,3; Guo, Xiao-Xiang1; Li, Jian-Xu1; Fan, Zhen1; Song, Wei-Meng1; Chen, Fang-Yan1; Ahati, Ruzha1; Wang, Ling-Jian1; Zhao, Qing4; Martin, Cathie4,5; Chen, Xiao-Ya1,4
Corresponding AuthorChen, Xiao-Ya(
AbstractIn plants, lineage-specific metabolites can be created by activities derived from the catalytic promiscuity of ancestral proteins, although examples of recruiting detoxification systems to biosynthetic pathways are scarce. The ubiquitous glyoxalase (GLX) system scavenges the cytotoxic methylglyoxal, in which GLXI isomerizes the alpha-hydroxy carbonyl in the methylglyoxal-glutathione adduct for subsequent hydrolysis. We show that GLXIs across kingdoms are more promiscuous than recognized previously and can act as aromatases without cofactors. In cotton, a specialized GLXI variant, SPG, has lost its GSH-binding sites and organelle-targeting signal, and evolved to aromatize cyclic sesquiterpenes bearing alpha-hydroxyketones to synthesize defense compounds in the cytosol. Notably, SPG is able to transform acetylated deoxynivalenol, the prevalent mycotoxin contaminating cereals and foods. We propose that detoxification enzymes are a valuable source of new catalytic functions and SPG, a standalone enzyme catalyzing complex reactions, has potential for toxin degradation, crop engineering and design of novel aromatics.
Indexed BySCI ; SCI
WOS IDWOS:000508456400002
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Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorChen, Xiao-Ya
Affiliation1.Univ CAS, Chinese Acad Sci, State Key Lab Plant Mol Genet, CAS Ctr Excellence Mol Plant Sci,Shanghai Inst Pl, Shanghai, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
4.Chinese Acad Sci, Shanghai Chenshan Plant Sci Res Ctr, Shanghai Chenshan Bot Garden, Shanghai Key Lab Plant Funct Genom & Resources, Shanghai, Peoples R China
5.John Innes Ctr, Norwich, Norfolk, England
Recommended Citation
GB/T 7714
Huang, Jin-Quan,Fang, Xin,Tian, Xiu,et al. Aromatization of natural products by a specialized detoxification enzyme[J]. NATURE CHEMICAL BIOLOGY,2020,16(3):11.
APA Huang, Jin-Quan.,Fang, Xin.,Tian, Xiu.,Chen, Ping.,Lin, Jia-Ling.,...&Chen, Xiao-Ya.(2020).Aromatization of natural products by a specialized detoxification enzyme.NATURE CHEMICAL BIOLOGY,16(3),11.
MLA Huang, Jin-Quan,et al."Aromatization of natural products by a specialized detoxification enzyme".NATURE CHEMICAL BIOLOGY 16.3(2020):11.
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