Melotenuines A-E, cytotoxic monoterpenoid indole alkaloids from Melodinus tenuicaudatus
Liu, Jian-Wen1,2; Huo, Zong-Qing2; Zhao, Qian2; Hao, Xiao-Jiang2; He, Hong-Ping1; Zhang, Yu2
Corresponding AuthorHe, Hong-Ping(hehongping@yahoo.com) ; Zhang, Yu(zhangyu@mail.kib.ac.cn)
2019-10-01
Source PublicationFITOTERAPIA
ISSN0367-326X
Volume138Pages:7
AbstractFive new monoterpenoid indole alkaloids, melotenuines A-E (1-5), along with 18 known indole alkaloids, were isolated from the twigs and leaves of Melodinus tenuicaudatus. The structures of the new alkaloids were determined by a combination of MS, NMR and ECD analysis. Melotenuine A (1) represents the first example of aspidosperma-meloscandonine type bisindole alkaloids characterized by a methylene bridge between the two monomers, while melotenuine B (2) possessed a rare eburnamine-melsocandonine skeleton. All of the new indole alkaloids were evaluated for in vitro cytotoxicities against five human cancer cell lines. Among them, alkaloid 4 showed specific cytotoxicity against HL-60 cell line with IC 50 value (5.15 +/- 0.16 mu M) comparable with that of positive control.
KeywordMelodinus tenuicaudatus Monoterpenoid indole alkaloids Melotenuines A-E Aspidosperma-meloscandonine type
DOI10.1016/j.fitote.2019.104347
Indexed BySCI ; SCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000498290700022
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/70470
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorHe, Hong-Ping; Zhang, Yu
Affiliation1.Yunnan Univ Tradit Chinese Med, Kunming 650500, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Liu, Jian-Wen,Huo, Zong-Qing,Zhao, Qian,et al. Melotenuines A-E, cytotoxic monoterpenoid indole alkaloids from Melodinus tenuicaudatus[J]. FITOTERAPIA,2019,138:7.
APA Liu, Jian-Wen,Huo, Zong-Qing,Zhao, Qian,Hao, Xiao-Jiang,He, Hong-Ping,&Zhang, Yu.(2019).Melotenuines A-E, cytotoxic monoterpenoid indole alkaloids from Melodinus tenuicaudatus.FITOTERAPIA,138,7.
MLA Liu, Jian-Wen,et al."Melotenuines A-E, cytotoxic monoterpenoid indole alkaloids from Melodinus tenuicaudatus".FITOTERAPIA 138(2019):7.
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