Melotenuines A-E, cytotoxic monoterpenoid indole alkaloids from Melodinus tenuicaudatus

doi:10.1016/j.fitote.2019.104347

	Melotenuines A-E, cytotoxic monoterpenoid indole alkaloids from Melodinus tenuicaudatus
	Liu, Jian-Wen 1,2; Huo, Zong-Qing 2; Zhao, Qian 2; Hao, Xiao-Jiang2 ; He, Hong-Ping 1; Zhang, Yu2
通讯作者	He, Hong-Ping(hehongping@yahoo.com) ; Zhang, Yu(zhangyu@mail.kib.ac.cn)
	2019-10-01
发表期刊	FITOTERAPIA
ISSN	0367-326X
卷号	138 页码:7
摘要	Five new monoterpenoid indole alkaloids, melotenuines A-E (1-5), along with 18 known indole alkaloids, were isolated from the twigs and leaves of Melodinus tenuicaudatus. The structures of the new alkaloids were determined by a combination of MS, NMR and ECD analysis. Melotenuine A (1) represents the first example of aspidosperma-meloscandonine type bisindole alkaloids characterized by a methylene bridge between the two monomers, while melotenuine B (2) possessed a rare eburnamine-melsocandonine skeleton. All of the new indole alkaloids were evaluated for in vitro cytotoxicities against five human cancer cell lines. Among them, alkaloid 4 showed specific cytotoxicity against HL-60 cell line with IC 50 value (5.15 +/- 0.16 mu M) comparable with that of positive control.
关键词	Melodinus tenuicaudatus Monoterpenoid indole alkaloids Melotenuines A-E Aspidosperma-meloscandonine type
DOI	10.1016/j.fitote.2019.104347
收录类别	SCI ; SCI
语种	英语
WOS记录号	WOS:000498290700022
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/70470
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	He, Hong-Ping; Zhang, Yu
作者单位	1.Yunnan Univ Tradit Chinese Med, Kunming 650500, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Liu, Jian-Wen,Huo, Zong-Qing,Zhao, Qian,et al. Melotenuines A-E, cytotoxic monoterpenoid indole alkaloids from Melodinus tenuicaudatus[J]. FITOTERAPIA,2019,138:7.
APA	Liu, Jian-Wen,Huo, Zong-Qing,Zhao, Qian,Hao, Xiao-Jiang,He, Hong-Ping,&Zhang, Yu.(2019).Melotenuines A-E, cytotoxic monoterpenoid indole alkaloids from Melodinus tenuicaudatus.FITOTERAPIA,138,7.
MLA	Liu, Jian-Wen,et al."Melotenuines A-E, cytotoxic monoterpenoid indole alkaloids from Melodinus tenuicaudatus".FITOTERAPIA 138(2019):7.

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