Commiphorines A and B, unprecedented sesquiterpenoid dimers from Resina Commiphora with striking activities on anti-inflammation and lipogenesis inhibition
Dong, Lu1,2; Qin, Da-Peng1; Di, Qian-Qian1; Liu, Ying1; Chen, Wei-Lin1; Wang, Shu-Mei3; Cheng, Yong-Xian1
Corresponding AuthorCheng, Yong-Xian(yxcheng@szu.edu.cn)
2019-12-07
Source PublicationORGANIC CHEMISTRY FRONTIERS
ISSN2052-4129
Volume6Issue:23Pages:3825-3833
AbstractCommiphorines A (1), an unprecedented sesquiterpenoid heterodimer featuring a 5/7(5)/4/10/5 ring system, and B (2), a dimeric sesquiterpenoid possessing an unusual 1,4-dioxin motif and a 6/6/5/6/6/6 polycyclic system, and two intermediates 3 and 4 were isolated from Resina Commiphora. A plausible biosynthetic route for 1 and 2 was proposed. Compound 2 could significantly suppress LPS-induced inflammation through NF-kappa B and MAPK signaling pathways in mouse peritoneal macrophages. Compounds 1 and 2 could inhibit lipid synthesis in HepG2 cells.
DOI10.1039/c9qo01046g
Indexed BySCI ; SCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000498642500015
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/70435
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorCheng, Yong-Xian
Affiliation1.Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Guangdong Key Lab Genome Stabil & Dis Prevent, Shenzhen 518060, Guangdong, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Guangdong Pharmaceut Univ, Guangzhou 510006, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Dong, Lu,Qin, Da-Peng,Di, Qian-Qian,et al. Commiphorines A and B, unprecedented sesquiterpenoid dimers from Resina Commiphora with striking activities on anti-inflammation and lipogenesis inhibition[J]. ORGANIC CHEMISTRY FRONTIERS,2019,6(23):3825-3833.
APA Dong, Lu.,Qin, Da-Peng.,Di, Qian-Qian.,Liu, Ying.,Chen, Wei-Lin.,...&Cheng, Yong-Xian.(2019).Commiphorines A and B, unprecedented sesquiterpenoid dimers from Resina Commiphora with striking activities on anti-inflammation and lipogenesis inhibition.ORGANIC CHEMISTRY FRONTIERS,6(23),3825-3833.
MLA Dong, Lu,et al."Commiphorines A and B, unprecedented sesquiterpenoid dimers from Resina Commiphora with striking activities on anti-inflammation and lipogenesis inhibition".ORGANIC CHEMISTRY FRONTIERS 6.23(2019):3825-3833.
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