| Commiphorines A and B, unprecedented sesquiterpenoid dimers from Resina Commiphora with striking activities on anti-inflammation and lipogenesis inhibition | |
| Dong, Lu1,2; Qin, Da-Peng1; Di, Qian-Qian1; Liu, Ying1; Chen, Wei-Lin1; Wang, Shu-Mei3; Cheng, Yong-Xian1 | |
| Corresponding Author | Cheng, Yong-Xian(yxcheng@szu.edu.cn) |
| 2019-12-07 | |
| Source Publication | ORGANIC CHEMISTRY FRONTIERS
 |
| ISSN | 2052-4129 |
| Volume | 6Issue:23Pages:3825-3833 |
| Abstract | Commiphorines A (1), an unprecedented sesquiterpenoid heterodimer featuring a 5/7(5)/4/10/5 ring system, and B (2), a dimeric sesquiterpenoid possessing an unusual 1,4-dioxin motif and a 6/6/5/6/6/6 polycyclic system, and two intermediates 3 and 4 were isolated from Resina Commiphora. A plausible biosynthetic route for 1 and 2 was proposed. Compound 2 could significantly suppress LPS-induced inflammation through NF-kappa B and MAPK signaling pathways in mouse peritoneal macrophages. Compounds 1 and 2 could inhibit lipid synthesis in HepG2 cells. |
| DOI | 10.1039/c9qo01046g |
| Indexed By | SCI ; SCI |
| Language | 英语 |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Organic |
| WOS ID | WOS:000498642500015 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/70435 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Cheng, Yong-Xian |
| Affiliation | 1.Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Guangdong Key Lab Genome Stabil & Dis Prevent, Shenzhen 518060, Guangdong, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Guangdong Pharmaceut Univ, Guangzhou 510006, Guangdong, Peoples R China |
| Recommended Citation GB/T 7714 | Dong, Lu,Qin, Da-Peng,Di, Qian-Qian,et al. Commiphorines A and B, unprecedented sesquiterpenoid dimers from Resina Commiphora with striking activities on anti-inflammation and lipogenesis inhibition[J]. ORGANIC CHEMISTRY FRONTIERS,2019,6(23):3825-3833. |
| APA | Dong, Lu.,Qin, Da-Peng.,Di, Qian-Qian.,Liu, Ying.,Chen, Wei-Lin.,...&Cheng, Yong-Xian.(2019).Commiphorines A and B, unprecedented sesquiterpenoid dimers from Resina Commiphora with striking activities on anti-inflammation and lipogenesis inhibition.ORGANIC CHEMISTRY FRONTIERS,6(23),3825-3833. |
| MLA | Dong, Lu,et al."Commiphorines A and B, unprecedented sesquiterpenoid dimers from Resina Commiphora with striking activities on anti-inflammation and lipogenesis inhibition".ORGANIC CHEMISTRY FRONTIERS 6.23(2019):3825-3833. |
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| cheng2019.pdf（2250KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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