Hyphenone A, the first 3,3-diisoprenylated bicyclic polyprenylated acylphloroglucinols as Ca(v)3.1 T-type calcium channel inhibitor from Hypericum henryi
Jiang, Na-Na1,2,5; Du, Shu-Zong3,4,5; Ye, Yan-Song1,2,5; Yan, Hui1,2; Yang, Xing-Wei1,2; Yang, Jian3,4; Nian, Yin3,4; Xu, Gang1,2
Corresponding AuthorNian, Yin(nianyin@mail.kiz.ac.cn) ; Xu, Gang(xugang008@mail.kib.ac.cn)
2019-11-07
Source PublicationTETRAHEDRON LETTERS
ISSN0040-4039
Volume60Issue:45Pages:5
AbstractHyphenone A (1), a new type of bicyclic polyprenylated acylphloroglucinols (BPAPs) featured with an unprecedented 3,3-diisoprenylated 1,3,5-trione core, were characterized from the roots of Hypericum henryi together with two new congeners (hyphenones B-C, 2-3) and five known biosynthetic related PPAPs. Biogenetically, 1 should be derived from a novel 3,3,5,5-tetraisoprenylated MPAPs precursor. Their structures were elucidated by comprehensive spectroscopic data and X-ray diffraction. Moreover, 1-3 were identified as the first PPAPs type Ca(v)3.1 T-type calcium channel (TTCC) inhibitors, with IC50 values of 7.07, 6.19, and 5.47 mu M, respectively. (C) 2019 Elsevier Ltd. All rights reserved.
KeywordPolyprenylated acylphloroglucinol Hyphenone A Hypericum henryi Ca(v)3.1 T-type calcium channel
DOI10.1016/j.tetlet.2019.151220
Indexed BySCI ; SCI
Language英语
WOS IDWOS:000495490500006
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/70191
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorNian, Yin; Xu, Gang
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
3.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
4.Chinese Acad Sci, Ion Channel Res & Drug Dev Ctr, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Jiang, Na-Na,Du, Shu-Zong,Ye, Yan-Song,et al. Hyphenone A, the first 3,3-diisoprenylated bicyclic polyprenylated acylphloroglucinols as Ca(v)3.1 T-type calcium channel inhibitor from Hypericum henryi[J]. TETRAHEDRON LETTERS,2019,60(45):5.
APA Jiang, Na-Na.,Du, Shu-Zong.,Ye, Yan-Song.,Yan, Hui.,Yang, Xing-Wei.,...&Xu, Gang.(2019).Hyphenone A, the first 3,3-diisoprenylated bicyclic polyprenylated acylphloroglucinols as Ca(v)3.1 T-type calcium channel inhibitor from Hypericum henryi.TETRAHEDRON LETTERS,60(45),5.
MLA Jiang, Na-Na,et al."Hyphenone A, the first 3,3-diisoprenylated bicyclic polyprenylated acylphloroglucinols as Ca(v)3.1 T-type calcium channel inhibitor from Hypericum henryi".TETRAHEDRON LETTERS 60.45(2019):5.
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