Total Synthesis of (+/-)-Cochlearol A
Zhang, Da-Wei1,2; Xu, Wen-Dan1,2; Fan, Hui-Lan1,2; Liu, Hao-Miao1,2; Chen, Dong1,2; Liu, Dan-Dan3,4; Qin, Hong-Bo1
Corresponding AuthorLiu, Dan-Dan( ; Qin, Hong-Bo(
Source PublicationORGANIC LETTERS
AbstractTotal synthesis of (+/-)-cochlearol A was accomplished, which features a cis 6/6 B/D ring synthesis. A TMSOTf-promoted lactonization of tert-butoxy ketoester produced the desired lactone with quaternary carbon. The cis configuration of the B/E ring is essential for regioselective B/D ring formation. Finally, simple deprotections and trans- formations gave cochlearol A in 16 steps from known ethyl 4-tert-butoxyacetoacetate.
Indexed BySCI
WOS IDWOS:000485089300036
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Document Type期刊论文
Corresponding AuthorLiu, Dan-Dan; Qin, Hong-Bo
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China
4.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Da-Wei,Xu, Wen-Dan,Fan, Hui-Lan,et al. Total Synthesis of (+/-)-Cochlearol A[J]. ORGANIC LETTERS,2019,21(17):6761-6764.
APA Zhang, Da-Wei.,Xu, Wen-Dan.,Fan, Hui-Lan.,Liu, Hao-Miao.,Chen, Dong.,...&Qin, Hong-Bo.(2019).Total Synthesis of (+/-)-Cochlearol A.ORGANIC LETTERS,21(17),6761-6764.
MLA Zhang, Da-Wei,et al."Total Synthesis of (+/-)-Cochlearol A".ORGANIC LETTERS 21.17(2019):6761-6764.
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