| Total Synthesis of (+/-)-Cochlearol A | |
Zhang, Da-Wei1,2; Xu, Wen-Dan1,2; Fan, Hui-Lan1,2; Liu, Hao-Miao1,2; Chen, Dong1,2; Liu, Dan-Dan3,4; Qin, Hong-Bo1
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| Corresponding Author | Liu, Dan-Dan(liudandan1017@qq.com) ; Qin, Hong-Bo(qinhongbo@mail.kib.ac.cn) |
| 2019-09-06 | |
| Source Publication | ORGANIC LETTERS
 |
| ISSN | 1523-7060 |
| Volume | 21Issue:17Pages:6761-6764 |
| Abstract | Total synthesis of (+/-)-cochlearol A was accomplished, which features a cis 6/6 B/D ring synthesis. A TMSOTf-promoted lactonization of tert-butoxy ketoester produced the desired lactone with quaternary carbon. The cis configuration of the B/E ring is essential for regioselective B/D ring formation. Finally, simple deprotections and trans- formations gave cochlearol A in 16 steps from known ethyl 4-tert-butoxyacetoacetate. |
| DOI | 10.1021/acs.orglett.9b02391 |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Organic |
| WOS ID | WOS:000485089300036 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/68714 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Liu, Dan-Dan; Qin, Hong-Bo |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China 4.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang, Da-Wei,Xu, Wen-Dan,Fan, Hui-Lan,et al. Total Synthesis of (+/-)-Cochlearol A[J]. ORGANIC LETTERS,2019,21(17):6761-6764. |
| APA | Zhang, Da-Wei.,Xu, Wen-Dan.,Fan, Hui-Lan.,Liu, Hao-Miao.,Chen, Dong.,...&Qin, Hong-Bo.(2019).Total Synthesis of (+/-)-Cochlearol A.ORGANIC LETTERS,21(17),6761-6764. |
| MLA | Zhang, Da-Wei,et al."Total Synthesis of (+/-)-Cochlearol A".ORGANIC LETTERS 21.17(2019):6761-6764. |
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