Total Synthesis of (+/-)-Cochlearol A

doi:10.1021/acs.orglett.9b02391

	Total Synthesis of (+/-)-Cochlearol A
	Zhang, Da-Wei 1,2; Xu, Wen-Dan 1,2; Fan, Hui-Lan 1,2; Liu, Hao-Miao 1,2; Chen, Dong 1,2; Liu, Dan-Dan 3,4; Qin, Hong-Bo1
通讯作者	Liu, Dan-Dan(liudandan1017@qq.com) ; Qin, Hong-Bo(qinhongbo@mail.kib.ac.cn)
	2019-09-06
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	21 期号:17 页码:6761-6764
摘要	Total synthesis of (+/-)-cochlearol A was accomplished, which features a cis 6/6 B/D ring synthesis. A TMSOTf-promoted lactonization of tert-butoxy ketoester produced the desired lactone with quaternary carbon. The cis configuration of the B/E ring is essential for regioselective B/D ring formation. Finally, simple deprotections and trans- formations gave cochlearol A in 16 steps from known ethyl 4-tert-butoxyacetoacetate.
DOI	10.1021/acs.orglett.9b02391
收录类别	SCI
语种	英语
WOS记录号	WOS:000485089300036
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/68714
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Liu, Dan-Dan; Qin, Hong-Bo
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China 4.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Da-Wei,Xu, Wen-Dan,Fan, Hui-Lan,et al. Total Synthesis of (+/-)-Cochlearol A[J]. ORGANIC LETTERS,2019,21(17):6761-6764.
APA	Zhang, Da-Wei.,Xu, Wen-Dan.,Fan, Hui-Lan.,Liu, Hao-Miao.,Chen, Dong.,...&Qin, Hong-Bo.(2019).Total Synthesis of (+/-)-Cochlearol A.ORGANIC LETTERS,21(17),6761-6764.
MLA	Zhang, Da-Wei,et al."Total Synthesis of (+/-)-Cochlearol A".ORGANIC LETTERS 21.17(2019):6761-6764.

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