Three new C23 steroids from the leaves and stems of Nicandra physaloides

doi:10.1016/j.steroids.2019.06.001

KIB OpenIR

	Three new C23 steroids from the leaves and stems of Nicandra physaloides
	Zhang, Ling 1,2; Peng, Xingrong 2; Zhao, Gaoting 2; Xia, Jianjun 1; Lu, Jing 2; Zhou, Lin 2; Wang, Kunmiao 1; Li, Zhihua 1; Qiu, Minghua2
Corresponding Author	Qiu, Minghua(mhchiu@mail.kib.ac.cn)
	2019-10-01
Source Publication	STEROIDS
ISSN	0039-128X
Volume	150 Pages:4
Abstract	Nicandra physaloides is a medicinal and edible plant and has been used as traditionally herbal medicine to treat various diseases in folk. Its characteristic withanolides, a kind of ergostane-type steroids, are reported to display plentiful biological activities that many explain the effect of N. physaloides to some extent. Thus, to further find bioactive steroids, the stems and leaves of N. physaloides were investigated and three new C23 steroids, nic-physatones I-J (1-2), and nic-physatone S (3), together with a known C25 steroid, nic 17 (4), were isolated. Their structures were elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, H-1-(1) H COSY, and ROESY), UV and MS analyses. Compounds 1-3 possess a rare C23 steroid skeleton. Among them, compound 3 represented the first example of a C23 steroid featuring a benzene ring (D ring). The isolated compounds showed no cytotoxic activity.
Keyword	Nicandra physaloides Solanaceae Withanolide C23 steroids
DOI	10.1016/j.steroids.2019.06.001
Indexed By	SCI
Language	英语
WOS ID	WOS:000486110300002
Citation statistics	Cited Times:3[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/68678
Collection	中国科学院昆明植物研究所
Corresponding Author	Qiu, Minghua
Affiliation	1.China Tobacco Yunnan Ind Co Ltd, R&D Ctr, Yunnan Key Lab Tobacco Chem, Kunming, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
Recommended Citation GB/T 7714	Zhang, Ling,Peng, Xingrong,Zhao, Gaoting,et al. Three new C23 steroids from the leaves and stems of Nicandra physaloides[J]. STEROIDS,2019,150:4.
APA	Zhang, Ling.,Peng, Xingrong.,Zhao, Gaoting.,Xia, Jianjun.,Lu, Jing.,...&Qiu, Minghua.(2019).Three new C23 steroids from the leaves and stems of Nicandra physaloides.STEROIDS,150,4.
MLA	Zhang, Ling,et al."Three new C23 steroids from the leaves and stems of Nicandra physaloides".STEROIDS 150(2019):4.

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