Three new C23 steroids from the leaves and stems of Nicandra physaloides
Zhang, Ling1,2; Peng, Xingrong2; Zhao, Gaoting2; Xia, Jianjun1; Lu, Jing2; Zhou, Lin2; Wang, Kunmiao1; Li, Zhihua1; Qiu, Minghua2
Corresponding AuthorQiu, Minghua(
Source PublicationSTEROIDS
AbstractNicandra physaloides is a medicinal and edible plant and has been used as traditionally herbal medicine to treat various diseases in folk. Its characteristic withanolides, a kind of ergostane-type steroids, are reported to display plentiful biological activities that many explain the effect of N. physaloides to some extent. Thus, to further find bioactive steroids, the stems and leaves of N. physaloides were investigated and three new C23 steroids, nic-physatones I-J (1-2), and nic-physatone S (3), together with a known C25 steroid, nic 17 (4), were isolated. Their structures were elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, H-1-(1) H COSY, and ROESY), UV and MS analyses. Compounds 1-3 possess a rare C23 steroid skeleton. Among them, compound 3 represented the first example of a C23 steroid featuring a benzene ring (D ring). The isolated compounds showed no cytotoxic activity.
KeywordNicandra physaloides Solanaceae Withanolide C23 steroids
Indexed BySCI
WOS IDWOS:000486110300002
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Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorQiu, Minghua
Affiliation1.China Tobacco Yunnan Ind Co Ltd, R&D Ctr, Yunnan Key Lab Tobacco Chem, Kunming, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Ling,Peng, Xingrong,Zhao, Gaoting,et al. Three new C23 steroids from the leaves and stems of Nicandra physaloides[J]. STEROIDS,2019,150:4.
APA Zhang, Ling.,Peng, Xingrong.,Zhao, Gaoting.,Xia, Jianjun.,Lu, Jing.,...&Qiu, Minghua.(2019).Three new C23 steroids from the leaves and stems of Nicandra physaloides.STEROIDS,150,4.
MLA Zhang, Ling,et al."Three new C23 steroids from the leaves and stems of Nicandra physaloides".STEROIDS 150(2019):4.
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