KIB OpenIR
Three new C23 steroids from the leaves and stems of Nicandra physaloides
Zhang, Ling1,2; Peng, Xingrong2; Zhao, Gaoting2; Xia, Jianjun1; Lu, Jing2; Zhou, Lin2; Wang, Kunmiao1; Li, Zhihua1; Qiu, Minghua2
Corresponding AuthorQiu, Minghua(mhchiu@mail.kib.ac.cn)
2019-10-01
Source PublicationSTEROIDS
ISSN0039-128X
Volume150Pages:4
AbstractNicandra physaloides is a medicinal and edible plant and has been used as traditionally herbal medicine to treat various diseases in folk. Its characteristic withanolides, a kind of ergostane-type steroids, are reported to display plentiful biological activities that many explain the effect of N. physaloides to some extent. Thus, to further find bioactive steroids, the stems and leaves of N. physaloides were investigated and three new C23 steroids, nic-physatones I-J (1-2), and nic-physatone S (3), together with a known C25 steroid, nic 17 (4), were isolated. Their structures were elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, H-1-(1) H COSY, and ROESY), UV and MS analyses. Compounds 1-3 possess a rare C23 steroid skeleton. Among them, compound 3 represented the first example of a C23 steroid featuring a benzene ring (D ring). The isolated compounds showed no cytotoxic activity.
KeywordNicandra physaloides Solanaceae Withanolide C23 steroids
DOI10.1016/j.steroids.2019.06.001
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS SubjectBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS IDWOS:000486110300002
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/68678
Collection中国科学院昆明植物研究所
Corresponding AuthorQiu, Minghua
Affiliation1.China Tobacco Yunnan Ind Co Ltd, R&D Ctr, Yunnan Key Lab Tobacco Chem, Kunming, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Ling,Peng, Xingrong,Zhao, Gaoting,et al. Three new C23 steroids from the leaves and stems of Nicandra physaloides[J]. STEROIDS,2019,150:4.
APA Zhang, Ling.,Peng, Xingrong.,Zhao, Gaoting.,Xia, Jianjun.,Lu, Jing.,...&Qiu, Minghua.(2019).Three new C23 steroids from the leaves and stems of Nicandra physaloides.STEROIDS,150,4.
MLA Zhang, Ling,et al."Three new C23 steroids from the leaves and stems of Nicandra physaloides".STEROIDS 150(2019):4.
Files in This Item: Download All
File Name/Size DocType Version Access License
Zhang-2019-Three new(416KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, Ling]'s Articles
[Peng, Xingrong]'s Articles
[Zhao, Gaoting]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, Ling]'s Articles
[Peng, Xingrong]'s Articles
[Zhao, Gaoting]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Ling]'s Articles
[Peng, Xingrong]'s Articles
[Zhao, Gaoting]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Zhang-2019-Three new C23 steroids from the lea.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.