Three new C23 steroids from the leaves and stems of Nicandra physaloides

doi:10.1016/j.steroids.2019.06.001

KIB OpenIR

	Three new C23 steroids from the leaves and stems of Nicandra physaloides
	Zhang, Ling 1,2; Peng, Xingrong 2; Zhao, Gaoting 2; Xia, Jianjun 1; Lu, Jing 2; Zhou, Lin 2; Wang, Kunmiao 1; Li, Zhihua 1; Qiu, Minghua2
通讯作者	Qiu, Minghua(mhchiu@mail.kib.ac.cn)
	2019-10-01
发表期刊	STEROIDS
ISSN	0039-128X
卷号	150 页码:4
摘要	Nicandra physaloides is a medicinal and edible plant and has been used as traditionally herbal medicine to treat various diseases in folk. Its characteristic withanolides, a kind of ergostane-type steroids, are reported to display plentiful biological activities that many explain the effect of N. physaloides to some extent. Thus, to further find bioactive steroids, the stems and leaves of N. physaloides were investigated and three new C23 steroids, nic-physatones I-J (1-2), and nic-physatone S (3), together with a known C25 steroid, nic 17 (4), were isolated. Their structures were elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, H-1-(1) H COSY, and ROESY), UV and MS analyses. Compounds 1-3 possess a rare C23 steroid skeleton. Among them, compound 3 represented the first example of a C23 steroid featuring a benzene ring (D ring). The isolated compounds showed no cytotoxic activity.
关键词	Nicandra physaloides Solanaceae Withanolide C23 steroids
DOI	10.1016/j.steroids.2019.06.001
收录类别	SCI
语种	英语
WOS记录号	WOS:000486110300002
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/68678
专题	中国科学院昆明植物研究所
通讯作者	Qiu, Minghua
作者单位	1.China Tobacco Yunnan Ind Co Ltd, R&D Ctr, Yunnan Key Lab Tobacco Chem, Kunming, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ling,Peng, Xingrong,Zhao, Gaoting,et al. Three new C23 steroids from the leaves and stems of Nicandra physaloides[J]. STEROIDS,2019,150:4.
APA	Zhang, Ling.,Peng, Xingrong.,Zhao, Gaoting.,Xia, Jianjun.,Lu, Jing.,...&Qiu, Minghua.(2019).Three new C23 steroids from the leaves and stems of Nicandra physaloides.STEROIDS,150,4.
MLA	Zhang, Ling,et al."Three new C23 steroids from the leaves and stems of Nicandra physaloides".STEROIDS 150(2019):4.

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