| New anti-HBV norbisabolane sesquiterpenes from Phyllantus acidus | |
| Gu, Chen1; Yin, Ai-Ping2; Yuan, Hao-Yang1; Yang, Kong1; Luo, Jia1; Zhan, Ying-Jun3; Yang, Chong-Ren3; Zuo, Da-Min2; Li, Hai-Zhou1; Xu, Min1 | |
| 通讯作者 | Li, Hai-Zhou(haizhouli@hotmail.com) ; Xu, Min(xumin8121@hotmail.com) |
| 2019-09-01 | |
| 发表期刊 | FITOTERAPIA
 |
| ISSN | 0367-326X |
| 卷号 | 137页码:7 |
| 摘要 | The norbisabolane-type sesquiterpenoids bearing a spiroketal functionality have been found in Phyllanthus spp. and showed anti-HBV activities. As part of an ongoing effort to search for promising anti-HBV sesquiterpenes from Phyllanthus plants, we report four new norbisabolane-type sesquiterpenoids, phyacidusin A (1), phyacidusin B (2), phllanthacidoid A1 (3) and phllanthacidoid N1 (4), from stem of P. acidus collected in Xishuangbanna, Yunnan province, China. The absolute configuration of new compounds was established by coupling constants and ROESY correlations, as well as comparation of NMR data with those of known compounds. The absolute configuration of new compounds 1 and 2 was further confirmed by X-ray diffraction. Compound 2 showed effect to HBsAg with an IC50 value of 11.2 +/- 0.01 mu M, while compound 3 inhibited HBeAg secretion with an IC50 value of 57.1 +/- 0.02 mu M. The results enriched the diversity of anti-HBV norbisabolane sesquiterpenes. |
| 关键词 | Phyllanthus acidus Norbisabolane-type sesquiterpenoid Anti-HBV |
| DOI | 10.1016/j.fitote.2019.04.006 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000484878400060 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/68604 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Li, Hai-Zhou; Xu, Min |
| 作者单位 | 1.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Ctr Pharmaceut Sci, Chenggong Campus, Kunming 650500, Yunnan, Peoples R China 2.Southern Med Univ, Sch Basic Med Sci, Dept Immunol, Guangzhou 510515, Guangdong, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gu, Chen,Yin, Ai-Ping,Yuan, Hao-Yang,et al. New anti-HBV norbisabolane sesquiterpenes from Phyllantus acidus[J]. FITOTERAPIA,2019,137:7. |
| APA | Gu, Chen.,Yin, Ai-Ping.,Yuan, Hao-Yang.,Yang, Kong.,Luo, Jia.,...&Xu, Min.(2019).New anti-HBV norbisabolane sesquiterpenes from Phyllantus acidus.FITOTERAPIA,137,7. |
| MLA | Gu, Chen,et al."New anti-HBV norbisabolane sesquiterpenes from Phyllantus acidus".FITOTERAPIA 137(2019):7. |
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| Gu-2019-New anti-HBV（822KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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