New anti-HBV norbisabolane sesquiterpenes from Phyllantus acidus
Gu, Chen1; Yin, Ai-Ping2; Yuan, Hao-Yang1; Yang, Kong1; Luo, Jia1; Zhan, Ying-Jun3; Yang, Chong-Ren3; Zuo, Da-Min2; Li, Hai-Zhou1; Xu, Min1
Corresponding AuthorLi, Hai-Zhou(haizhouli@hotmail.com) ; Xu, Min(xumin8121@hotmail.com)
2019-09-01
Source PublicationFITOTERAPIA
ISSN0367-326X
Volume137Pages:7
AbstractThe norbisabolane-type sesquiterpenoids bearing a spiroketal functionality have been found in Phyllanthus spp. and showed anti-HBV activities. As part of an ongoing effort to search for promising anti-HBV sesquiterpenes from Phyllanthus plants, we report four new norbisabolane-type sesquiterpenoids, phyacidusin A (1), phyacidusin B (2), phllanthacidoid A1 (3) and phllanthacidoid N1 (4), from stem of P. acidus collected in Xishuangbanna, Yunnan province, China. The absolute configuration of new compounds was established by coupling constants and ROESY correlations, as well as comparation of NMR data with those of known compounds. The absolute configuration of new compounds 1 and 2 was further confirmed by X-ray diffraction. Compound 2 showed effect to HBsAg with an IC50 value of 11.2 +/- 0.01 mu M, while compound 3 inhibited HBeAg secretion with an IC50 value of 57.1 +/- 0.02 mu M. The results enriched the diversity of anti-HBV norbisabolane sesquiterpenes.
KeywordPhyllanthus acidus Norbisabolane-type sesquiterpenoid Anti-HBV
DOI10.1016/j.fitote.2019.04.006
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000484878400060
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/68604
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLi, Hai-Zhou; Xu, Min
Affiliation1.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Ctr Pharmaceut Sci, Chenggong Campus, Kunming 650500, Yunnan, Peoples R China
2.Southern Med Univ, Sch Basic Med Sci, Dept Immunol, Guangzhou 510515, Guangdong, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Gu, Chen,Yin, Ai-Ping,Yuan, Hao-Yang,et al. New anti-HBV norbisabolane sesquiterpenes from Phyllantus acidus[J]. FITOTERAPIA,2019,137:7.
APA Gu, Chen.,Yin, Ai-Ping.,Yuan, Hao-Yang.,Yang, Kong.,Luo, Jia.,...&Xu, Min.(2019).New anti-HBV norbisabolane sesquiterpenes from Phyllantus acidus.FITOTERAPIA,137,7.
MLA Gu, Chen,et al."New anti-HBV norbisabolane sesquiterpenes from Phyllantus acidus".FITOTERAPIA 137(2019):7.
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