Anti-inflammatory Effect of Pomelo Peel and Its Bioactive Coumarins
Zhao, Yun-Li1,2; Yang, Xiong-Wu2; Wu, Bai-Fen3; Shang, Jian-Hua2; Liu, Ya-Ping2; Zhi-Dai1; Luo, Xiao-Dong1,2
Corresponding AuthorLuo, Xiao-Dong(
AbstractCitrus grandis (L.) Osbeck is a popular fruit cultivated around the world, and its peels are sometimes used for the treatment of cough, abdominal pain, and indigestion in China. However, the peel is discarded after fruit consumption in most cases, and its chemical constituents and biological activities have not been validated before. The present study focused on evaluation of the chemical and pharmacological profile of coumarins from peels of C. grandis against inflammation. The extracts and phytochemicals from peels of C. grandis were prepared, and anti-inflammatory activities were carried out in vivo and in vitro, including inhibiting xylene-induced ear edema and carrageenan-induced paw edema in mice and the production of inflammatory cytokines (interleukin 1 beta, prostaglandin 2, and tumor-necrosis factor alpha) in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Results indicated that methanolic extract, ethyl acetate fraction, and four major coumarins (compounds 7, 8, 13, and 16) inhibited swelling induced by xylene and carrageenan, separately, in vivo. Furthermore, 18 coumarins inhibited inflammatory factor secretion in macrophages primed by LPS, in which compounds 4, 6, 7, 10, 17 showed the most pronounced change, which were comparable to dexamethasone. In summary, peel of C. grandis showed an anti-inflammatory effect and coumarin compounds were responsible for regulating inflammatory mediators and cytokines, which might provide a novel nutritional strategy for inflammatory diseases.
KeywordC. grandis coumarins anti-inflammatory effect lipopolysaccharide
Indexed BySCI
WOS IDWOS:000481563600011
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Document Type期刊论文
Corresponding AuthorLuo, Xiao-Dong
Affiliation1.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Yunnan Univ Chinese Med, Kunming 650500, Yunnan, Peoples R China
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Zhao, Yun-Li,Yang, Xiong-Wu,Wu, Bai-Fen,et al. Anti-inflammatory Effect of Pomelo Peel and Its Bioactive Coumarins[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2019,67(32):8810-8818.
APA Zhao, Yun-Li.,Yang, Xiong-Wu.,Wu, Bai-Fen.,Shang, Jian-Hua.,Liu, Ya-Ping.,...&Luo, Xiao-Dong.(2019).Anti-inflammatory Effect of Pomelo Peel and Its Bioactive Coumarins.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,67(32),8810-8818.
MLA Zhao, Yun-Li,et al."Anti-inflammatory Effect of Pomelo Peel and Its Bioactive Coumarins".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 67.32(2019):8810-8818.
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