Mangiterpenes A-C and 2 ',3 '-seco-manginoid C, four sesquiterpene/monoterpene-shikimate-conjugated spirocyclic meroterpenoids from Guignardia mangiferae

doi:10.1016/j.phytochem.2019.05.018

	Mangiterpenes A-C and 2 ',3 '-seco-manginoid C, four sesquiterpene/monoterpene-shikimate-conjugated spirocyclic meroterpenoids from Guignardia mangiferae
	Chen, Keliang 1; Chen, Chunmei 1; Guo, Jieru 1,3; Sun, Weiguang 1; Liu, Junjun 1; Yang, Jing2 ; Liu, Xiulan 3; Wang, Jianping 1; Luo, Zengwei 1; Zhu, Hucheng 1; Zhang, Yonghui 1
	2019-08-01
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	164 页码:236-242
摘要	Mangiterpenes A-C and 2',3'-seco-manginoid C, four undescribed sesquiterpene/monoterpene-shikimate-conjugated meroterpenoids with spiro ring systems, were isolated from Guignardia mangiferae. The structures and absolute configurations of these compounds were established by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. Mangiterpenes A-C represent the first examples of sesquiterpene-shikimate-conjugated spirocyclic meroterpenoids, and 2',3'-seco-manginoid C features an unexpected 2',3'-seco-manginoids skeleton. Mangiterpene C strongly inhibited the production of NO inducted by LPS, with an IC50 value of 5.97 mu M. It showed an anti-inflammatory effect by means of blocking in the NF-kappa B signaling pathway and decreasing the expression of inflammatory mediators.
关键词	Guignardia Mangiferae Spirocyclic Meroterpenoids Anti-inflammatory Nuclear Factor-kappa b (Nf-kappa b)
DOI	10.1016/j.phytochem.2019.05.018
收录类别	SCI
WOS记录号	WOS:000475996800027
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/68227
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Zhu, Hucheng; Zhang, Yonghui
作者单位	1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Chen, Keliang,Chen, Chunmei,Guo, Jieru,et al. Mangiterpenes A-C and 2 ',3 '-seco-manginoid C, four sesquiterpene/monoterpene-shikimate-conjugated spirocyclic meroterpenoids from Guignardia mangiferae[J]. PHYTOCHEMISTRY,2019,164:236-242.
APA	Chen, Keliang.,Chen, Chunmei.,Guo, Jieru.,Sun, Weiguang.,Liu, Junjun.,...&Zhang, Yonghui.(2019).Mangiterpenes A-C and 2 ',3 '-seco-manginoid C, four sesquiterpene/monoterpene-shikimate-conjugated spirocyclic meroterpenoids from Guignardia mangiferae.PHYTOCHEMISTRY,164,236-242.
MLA	Chen, Keliang,et al."Mangiterpenes A-C and 2 ',3 '-seco-manginoid C, four sesquiterpene/monoterpene-shikimate-conjugated spirocyclic meroterpenoids from Guignardia mangiferae".PHYTOCHEMISTRY 164(2019):236-242.

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