Chemical constituents from plant endophytic fungus Alternaria alternata
Wang, Ju-Tao1,2; Ma, Zong-Hui1; Wang, Guo-Kai1,2; Xu, Feng-Qing1,2; Yu, Yang3,4; Wang, Gang1,2; Peng, Dai-Yin1,2; Liu, Jin-Song1,2
Corresponding AuthorPeng, Dai-Yin(pengdy@ahtcm.edu.cn) ; Liu, Jin-Song(jinsongliu@ahtcm.edu.cn)
2019-07-13
Source PublicationNATURAL PRODUCT RESEARCH
ISSN1478-6419
Pages8
AbstractFive new natural compounds (1-5) along with four known ones, involving dibenzo-alpha-pyrone derivatives, a benzo-gamma-pyrone derivative and an amide-type compound were obtained from Alternaria alternata, an endophyte isolated from Paeonia lactiflora. The structures of these isolates were elucidated by intensive analysis of spectroscopic data including NMR, HRMS (ESI and EI), UV and IR spectra. Compounds (1-4) were evaluated for their cytotoxicities against five selected human tumourtumour cell lines (A-549, MDA-MB-231, MCF-7, KB and KB-VIN), and compound 3 exhibited activities against MDA-MB-231and MCF-7 with IC50 values of 20.1 mu M and 32.2 mu M. [GRAPHICS] .
KeywordAlternaria alternata Paeonia lactiflora benzo-alpha-pyrone derivatives cytotoxic activity
DOI10.1080/14786419.2019.1639699
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Applied ; Chemistry, Medicinal
WOS IDWOS:000478316400001
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/68203
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorPeng, Dai-Yin; Liu, Jin-Song
Affiliation1.Anhui Univ Chinese Med, Sch Pharm, Anhui Key Lab Modern Chinese Mat Med, Hefei, Anhui, Peoples R China
2.Synerget Innovat Ctr Anhui Authent Chinese Med Qu, Hefei, Anhui, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wang, Ju-Tao,Ma, Zong-Hui,Wang, Guo-Kai,et al. Chemical constituents from plant endophytic fungus Alternaria alternata[J]. NATURAL PRODUCT RESEARCH,2019:8.
APA Wang, Ju-Tao.,Ma, Zong-Hui.,Wang, Guo-Kai.,Xu, Feng-Qing.,Yu, Yang.,...&Liu, Jin-Song.(2019).Chemical constituents from plant endophytic fungus Alternaria alternata.NATURAL PRODUCT RESEARCH,8.
MLA Wang, Ju-Tao,et al."Chemical constituents from plant endophytic fungus Alternaria alternata".NATURAL PRODUCT RESEARCH (2019):8.
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