Salpratlactones A and B: A Pair of cis-trans Tautomeric Abietanes as Ca(v)3.1 T-Type Calcium Channel Agonists from Salvia prattii
Xia, Fan1,2,7; Li, Wen-Yan3,4,7; Yang, Xing-Wei1,2; Yang, Jian3,4; Li, Xian5,6; Nian, Yin3,4; Xu, Gang1,2
Corresponding AuthorLi, Xian(xianlikm@163.com) ; Nian, Yin(nianyin@mail.kiz.ac.cn) ; Xu, Gang(xugang008@mail.kib.ac.cn)
2019-07-19
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume21Issue:14Pages:5670-5674
AbstractSalpratlactones A (1) and B (2), a pair of abietane cis-trans tautomers from Salvia prattii, were identified as the first naturally occurring agonists of T-type calcium channel (TTCC). Structurally, 1 and 2 were featured by unique 6/5 carbocyclic rings bearing a gamma-lactone ring through an exocyclic double bond. Moreover, both compounds and their mixture at 10 mu M potently and equally increased Ca(v)3.1 TTCC peak currents, and 1 had an EC50 value of 12.48 mu M.
DOI10.1021/acs.orglett.9b01527
Indexed BySCI
Language英语
WOS IDWOS:000476957200062
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/68188
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLi, Xian; Nian, Yin; Xu, Gang
Affiliation1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
3.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China
4.Chinese Acad Sci, Ion Channel Res & Drug Dev Ctr, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China
5.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China
6.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China
7.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Xia, Fan,Li, Wen-Yan,Yang, Xing-Wei,et al. Salpratlactones A and B: A Pair of cis-trans Tautomeric Abietanes as Ca(v)3.1 T-Type Calcium Channel Agonists from Salvia prattii[J]. ORGANIC LETTERS,2019,21(14):5670-5674.
APA Xia, Fan.,Li, Wen-Yan.,Yang, Xing-Wei.,Yang, Jian.,Li, Xian.,...&Xu, Gang.(2019).Salpratlactones A and B: A Pair of cis-trans Tautomeric Abietanes as Ca(v)3.1 T-Type Calcium Channel Agonists from Salvia prattii.ORGANIC LETTERS,21(14),5670-5674.
MLA Xia, Fan,et al."Salpratlactones A and B: A Pair of cis-trans Tautomeric Abietanes as Ca(v)3.1 T-Type Calcium Channel Agonists from Salvia prattii".ORGANIC LETTERS 21.14(2019):5670-5674.
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