| Salpratlactones A and B: A Pair of cis-trans Tautomeric Abietanes as Ca(v)3.1 T-Type Calcium Channel Agonists from Salvia prattii | |
Xia, Fan1,2,7; Li, Wen-Yan3,4,7; Yang, Xing-Wei1,2 ; Yang, Jian3,4; Li, Xian5,6; Nian, Yin3,4; Xu, Gang1,2
| |
| 通讯作者 | Li, Xian(xianlikm@163.com) ; Nian, Yin(nianyin@mail.kiz.ac.cn) ; Xu, Gang(xugang008@mail.kib.ac.cn) |
| 2019-07-19 | |
| 发表期刊 | ORGANIC LETTERS
 |
| ISSN | 1523-7060 |
| 卷号 | 21期号:14页码:5670-5674 |
| 摘要 | Salpratlactones A (1) and B (2), a pair of abietane cis-trans tautomers from Salvia prattii, were identified as the first naturally occurring agonists of T-type calcium channel (TTCC). Structurally, 1 and 2 were featured by unique 6/5 carbocyclic rings bearing a gamma-lactone ring through an exocyclic double bond. Moreover, both compounds and their mixture at 10 mu M potently and equally increased Ca(v)3.1 TTCC peak currents, and 1 had an EC50 value of 12.48 mu M. |
| DOI | 10.1021/acs.orglett.9b01527 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000476957200062 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/68188 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Li, Xian; Nian, Yin; Xu, Gang |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 3.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China 4.Chinese Acad Sci, Ion Channel Res & Drug Dev Ctr, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China 5.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China 6.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China 7.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xia, Fan,Li, Wen-Yan,Yang, Xing-Wei,et al. Salpratlactones A and B: A Pair of cis-trans Tautomeric Abietanes as Ca(v)3.1 T-Type Calcium Channel Agonists from Salvia prattii[J]. ORGANIC LETTERS,2019,21(14):5670-5674. |
| APA | Xia, Fan.,Li, Wen-Yan.,Yang, Xing-Wei.,Yang, Jian.,Li, Xian.,...&Xu, Gang.(2019).Salpratlactones A and B: A Pair of cis-trans Tautomeric Abietanes as Ca(v)3.1 T-Type Calcium Channel Agonists from Salvia prattii.ORGANIC LETTERS,21(14),5670-5674. |
| MLA | Xia, Fan,et al."Salpratlactones A and B: A Pair of cis-trans Tautomeric Abietanes as Ca(v)3.1 T-Type Calcium Channel Agonists from Salvia prattii".ORGANIC LETTERS 21.14(2019):5670-5674. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Xia-2019-Salpratlact（980KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论