Hepatoprotective steroids from roots of Cynanchum otophyllum

doi:10.1016/j.fitote.2019.104171

	Hepatoprotective steroids from roots of Cynanchum otophyllum
	Dong, Jinrun 1,2,3; Peng, Xingrong 1,3; Lu, Shuangyang 1,2,3; Zhou, Lin 1,3; Qiu, Minghua1,3
通讯作者	Qiu, Minghua(mhchiu@mail.kib.ac.cn)
	2019-07-01
发表期刊	FITOTERAPIA
ISSN	0367-326X
卷号	136 页码:7
摘要	Seven undescribed C21 steroids, namely cynanchin A-G, together with thirteen known analogues, were isolated from the roots of cynanchum otophyllum. Their structures were elucidated by 1D, 2D NMR and MS spectra, as well as chemical methods. Meanwhile, all of isolates were tested for their anti-hepatic fibrosis activity. Among them, compounds 4-6, 10-12 and 14-17 showed moderate or significant inhibitory effects for the proliferation of hepatic stellate cells (HSCs) induced by transforming growth factor-beta 1 (TGF-beta 1) in vitro.
关键词	Cynanchum otophyllum Asclepiadaceae Steriods Anti-liver fibrosis activity
DOI	10.1016/j.fitote.2019.104171
收录类别	SCI
语种	英语
WOS记录号	WOS:000474320500017
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/67952
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Qiu, Minghua
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Dong, Jinrun,Peng, Xingrong,Lu, Shuangyang,et al. Hepatoprotective steroids from roots of Cynanchum otophyllum[J]. FITOTERAPIA,2019,136:7.
APA	Dong, Jinrun,Peng, Xingrong,Lu, Shuangyang,Zhou, Lin,&Qiu, Minghua.(2019).Hepatoprotective steroids from roots of Cynanchum otophyllum.FITOTERAPIA,136,7.
MLA	Dong, Jinrun,et al."Hepatoprotective steroids from roots of Cynanchum otophyllum".FITOTERAPIA 136(2019):7.

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