| Hepatoprotective steroids from roots of Cynanchum otophyllum | |
Dong, Jinrun1,2,3; Peng, Xingrong1,3; Lu, Shuangyang1,2,3; Zhou, Lin1,3; Qiu, Minghua1,3
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| Corresponding Author | Qiu, Minghua(mhchiu@mail.kib.ac.cn) |
| 2019-07-01 | |
| Source Publication | FITOTERAPIA
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| ISSN | 0367-326X |
| Volume | 136Pages:7 |
| Abstract | Seven undescribed C21 steroids, namely cynanchin A-G, together with thirteen known analogues, were isolated from the roots of cynanchum otophyllum. Their structures were elucidated by 1D, 2D NMR and MS spectra, as well as chemical methods. Meanwhile, all of isolates were tested for their anti-hepatic fibrosis activity. Among them, compounds 4-6, 10-12 and 14-17 showed moderate or significant inhibitory effects for the proliferation of hepatic stellate cells (HSCs) induced by transforming growth factor-beta 1 (TGF-beta 1) in vitro. |
| Keyword | Cynanchum otophyllum Asclepiadaceae Steriods Anti-liver fibrosis activity |
| DOI | 10.1016/j.fitote.2019.104171 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000474320500017 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/67952 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Qiu, Minghua |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China |
| Recommended Citation GB/T 7714 | Dong, Jinrun,Peng, Xingrong,Lu, Shuangyang,et al. Hepatoprotective steroids from roots of Cynanchum otophyllum[J]. FITOTERAPIA,2019,136:7. |
| APA | Dong, Jinrun,Peng, Xingrong,Lu, Shuangyang,Zhou, Lin,&Qiu, Minghua.(2019).Hepatoprotective steroids from roots of Cynanchum otophyllum.FITOTERAPIA,136,7. |
| MLA | Dong, Jinrun,et al."Hepatoprotective steroids from roots of Cynanchum otophyllum".FITOTERAPIA 136(2019):7. |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| Dong-2019-Hepatoprot（466KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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