Hepatoprotective steroids from roots of Cynanchum otophyllum
Dong, Jinrun1,2,3; Peng, Xingrong1,3; Lu, Shuangyang1,2,3; Zhou, Lin1,3; Qiu, Minghua1,3
通讯作者Qiu, Minghua(mhchiu@mail.kib.ac.cn)
2019-07-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号136页码:7
摘要Seven undescribed C21 steroids, namely cynanchin A-G, together with thirteen known analogues, were isolated from the roots of cynanchum otophyllum. Their structures were elucidated by 1D, 2D NMR and MS spectra, as well as chemical methods. Meanwhile, all of isolates were tested for their anti-hepatic fibrosis activity. Among them, compounds 4-6, 10-12 and 14-17 showed moderate or significant inhibitory effects for the proliferation of hepatic stellate cells (HSCs) induced by transforming growth factor-beta 1 (TGF-beta 1) in vitro.
关键词Cynanchum otophyllum Asclepiadaceae Steriods Anti-liver fibrosis activity
DOI10.1016/j.fitote.2019.104171
收录类别SCI
语种英语
WOS记录号WOS:000474320500017
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/67952
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Qiu, Minghua
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
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Dong, Jinrun,Peng, Xingrong,Lu, Shuangyang,et al. Hepatoprotective steroids from roots of Cynanchum otophyllum[J]. FITOTERAPIA,2019,136:7.
APA Dong, Jinrun,Peng, Xingrong,Lu, Shuangyang,Zhou, Lin,&Qiu, Minghua.(2019).Hepatoprotective steroids from roots of Cynanchum otophyllum.FITOTERAPIA,136,7.
MLA Dong, Jinrun,et al."Hepatoprotective steroids from roots of Cynanchum otophyllum".FITOTERAPIA 136(2019):7.
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