Highly functionalized cyclohexanone-monocyclic polyprenylated acylphloroglucinols from Hypericum perforatum induce leukemia cell apoptosis

doi:10.1039/c8qo01268g

	Highly functionalized cyclohexanone-monocyclic polyprenylated acylphloroglucinols from Hypericum perforatum induce leukemia cell apoptosis
	Guo, Yi 1; Tong, Qingyi 1; Zhang, Na 1; Duan, Xueyan 1; Cao, Yunfang 1; Zhu, Hucheng 1; Xie, Shuangshuang 1; Yang, Jing2 ; Zhang, Jinwen 3; Liu, Yanfei 4; Xue, Yongbo 1; Zhang, Yonghui 1
通讯作者	Xue, Yongbo(yongboxue@mail.hust.edu.cn) ; Zhang, Yonghui(zhangyh@mails.tjmu.edu.cn)
	2019-03-21
发表期刊	ORGANIC CHEMISTRY FRONTIERS
ISSN	2052-4129
卷号	6 期号:6 页码:817-824
摘要	Spirohypolactones A (1) and B (2) and hyperhexanones C-E (3-5), five degraded cyclohexanone-monocyclic polyprenylated acylphloroglucinol (C-MPAP) derivatives were isolated from the stems and leaves of Hypericum perforatum. The structures of these compounds were established by extensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 are the first examples of naturally occurring C-MPAPs possessing 2-oxaspiro[4.5]decane spirocyclic skeletons. Compound 5 featured an unusual dodecahydro-4H-oxocino[4,3-g]benzofuran ring system. Notably, compounds 3 and 4 induce apoptosis in the acute myeloid leukemia cell lines NB4 and HL-60 by the activation of caspase-3, and degradation of PARP. The proposed biosynthetic pathways and biological activities are also discussed.
DOI	10.1039/c8qo01268g
收录类别	SCI
语种	英语
WOS记录号	WOS:000462670600015
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/67690
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Xue, Yongbo; Zhang, Yonghui
作者单位	1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China 3.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Hubei, Peoples R China 4.Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp, Wuhan 430030, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Guo, Yi,Tong, Qingyi,Zhang, Na,et al. Highly functionalized cyclohexanone-monocyclic polyprenylated acylphloroglucinols from Hypericum perforatum induce leukemia cell apoptosis[J]. ORGANIC CHEMISTRY FRONTIERS,2019,6(6):817-824.
APA	Guo, Yi.,Tong, Qingyi.,Zhang, Na.,Duan, Xueyan.,Cao, Yunfang.,...&Zhang, Yonghui.(2019).Highly functionalized cyclohexanone-monocyclic polyprenylated acylphloroglucinols from Hypericum perforatum induce leukemia cell apoptosis.ORGANIC CHEMISTRY FRONTIERS,6(6),817-824.
MLA	Guo, Yi,et al."Highly functionalized cyclohexanone-monocyclic polyprenylated acylphloroglucinols from Hypericum perforatum induce leukemia cell apoptosis".ORGANIC CHEMISTRY FRONTIERS 6.6(2019):817-824.

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