Three new compounds with nitric oxide inhibitory activity from Tirpitzia sinensis, an ethnomedicinal plant from Southwest China

doi:10.1186/s13065-019-0568-9

	Three new compounds with nitric oxide inhibitory activity from Tirpitzia sinensis, an ethnomedicinal plant from Southwest China
	Gu, Ronghui 1; Wang, Yuehu2 ; Wu, Shibiao 3; Wang, Yeling 1; Li, Ping 1; Xu, Li 1; Zhou, Yue 1; Chen, Ze'e 1; Kennelly, Edward J.1,3,4; Long, Chunlin 1,2,5
通讯作者	Kennelly, Edward J.(edward.kennelly@lehman.cuny.edu) ; Long, Chunlin(long@mail.kib.ac.cn)
	2019-04-01
发表期刊	BMC CHEMISTRY
卷号	13 页码:12
摘要	The medicinal plant Tirpitzia sinensis has been used by the Zhuang ethnic people in mountainous areas of Southwest China to stop bleeding, invigorate blood circulation, and treat inflammation and wounds. In order to further explore its traditional medicinal uses, the phytochemical constituents of this species were examined. Three new compounds, the lignan tirpitzin (1), the flavonoid tirpitzoside (2), and the furan-glycoside tirpitziol (3), along with five known compounds were isolated from the aerial part of T. sinensis for the first time. The structures of these compounds were elucidated by 1D and 2D NMR, LC/MS, IR spectrometric methods and compared with published data. The results of an in silico pharmacophore-based analysis showed potential targets of the new compounds, including ERBB2, IRAK4, LCK, JAK2, MAPK14, and MMP-12. These targets suggested that 1-3 may be involved with wound-healing and/or inflammation, leading to an in vitro assay of nitric oxide (NO) inhibition assays with lipopolysaccharide-induced BV-2 cells. All three new compounds displayed moderate NO inhibitory activity with the IC50 values of 14.97 +/- 0.87, 26.63 +/- 1.32, and 17.09 +/- 2.3 mu M, respectively.
关键词	Tirpitzia sinensis Linaceae Lignans Inflammatory NO inhibition Pharmacological targets Pharmacophore In silico
DOI	10.1186/s13065-019-0568-9
收录类别	SCI
语种	英语
WOS记录号	WOS:000463050900004
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/67647
专题	资源植物与生物技术所级重点实验室
通讯作者	Kennelly, Edward J.; Long, Chunlin
作者单位	1.Minzu Univ China, Coll Life & Environm Sci, 27 Zhongguancun South Ave, Beijing 100081, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China 3.CUNY, Dept Biol Sci, Lehman Coll, 250 Bedford Pk Blvd West, Bronx, NY 10468 USA 4.CUNY, Grad Ctr, PhD Programs Biol, 365 Fifth Ave, New York, NY 10016 USA 5.Minzu Univ China, Key Lab Ethnomed, Minist Educ, 27 Zhongguancun South Ave, Beijing 100081, Peoples R China
推荐引用方式 GB/T 7714	Gu, Ronghui,Wang, Yuehu,Wu, Shibiao,et al. Three new compounds with nitric oxide inhibitory activity from Tirpitzia sinensis, an ethnomedicinal plant from Southwest China[J]. BMC CHEMISTRY,2019,13:12.
APA	Gu, Ronghui.,Wang, Yuehu.,Wu, Shibiao.,Wang, Yeling.,Li, Ping.,...&Long, Chunlin.(2019).Three new compounds with nitric oxide inhibitory activity from Tirpitzia sinensis, an ethnomedicinal plant from Southwest China.BMC CHEMISTRY,13,12.
MLA	Gu, Ronghui,et al."Three new compounds with nitric oxide inhibitory activity from Tirpitzia sinensis, an ethnomedicinal plant from Southwest China".BMC CHEMISTRY 13(2019):12.

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