Sphingofungins G and H: new five-membered lactones from Aspergillus penicilliodes Speg.

doi:10.1080/14786419.2018.1470627

	Sphingofungins G and H: new five-membered lactones from Aspergillus penicilliodes Speg.
	Zhang, Han 1,2; Zhu, Hong-Tao 1; Wang, Dong1 ; Yang, Chong-Ren 1; Zhang, Ying-Jun1,3
通讯作者	Zhang, Ying-Jun(zhangyj@mail.kib.ac.cn)
	2019-05-03
发表期刊	NATURAL PRODUCT RESEARCH
ISSN	1478-6419
卷号	33 期号:9 页码:1284-1291
摘要	Two new sphingofungins G (1) and H (2) with a five-membered lactone ring were identified from the solid-state fermentation of Aspergillus penicilliodes Speg., a dominant microorganism isolated previously from the post-fermentation of ripe Pu-er tea, together with six known metabolites. Their structures were elucidated by extensive spectroscopic methods. All of them were isolated from the mycelia culture of A. penicilliodes for the first time. The known compound, trypacidin, exhibited potent cytotoxities against five human cancer cell lines, e.g. myeloid leukemia HL-60, lung cancer A-549, hepatocellular carcinoma SMMC7721, breast cancer MCF-7, and colon cancer SW480, with IC50 values of 0.55, 11.45, 10.95, 3.58, and 3.49 mu M, resp., while cisplatin as the positive control, with IC50 values of 8.63, 24.15, 21.99, 27.29, and 23.61 mu M, resp. [GRAPHICS] .
关键词	Aspergillus penicilliodes Speg sphingofungins G and H cytotoxicity
DOI	10.1080/14786419.2018.1470627
收录类别	SCI
语种	英语
WOS记录号	WOS:000468074400008
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/67532
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Zhang, Ying-Jun
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Han,Zhu, Hong-Tao,Wang, Dong,et al. Sphingofungins G and H: new five-membered lactones from Aspergillus penicilliodes Speg.[J]. NATURAL PRODUCT RESEARCH,2019,33(9):1284-1291.
APA	Zhang, Han,Zhu, Hong-Tao,Wang, Dong,Yang, Chong-Ren,&Zhang, Ying-Jun.(2019).Sphingofungins G and H: new five-membered lactones from Aspergillus penicilliodes Speg..NATURAL PRODUCT RESEARCH,33(9),1284-1291.
MLA	Zhang, Han,et al."Sphingofungins G and H: new five-membered lactones from Aspergillus penicilliodes Speg.".NATURAL PRODUCT RESEARCH 33.9(2019):1284-1291.

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