Aromatic constituents from Ganoderma lucidum and their neuroprotective and anti-inflammatory activities
Lu, Shuang-Yang1,2; Peng, Xing-Rong1; Dong, Jin-Run1,2; Yan, Hui1; Kong, Qing-Hua1; Shi, Qiang-Qiang1,2; Li, Da-Shan1; Zhou, Lin1; Li, Zhong-Rong1; Qiu, Ming-Hua1,2
Corresponding AuthorQiu, Ming-Hua(mhchiu@mail.kib.ac.cn)
2019-04-01
Source PublicationFITOTERAPIA
ISSN0367-326X
Volume134Pages:58-64
AbstractFive new aromatic compounds, designed as lucidumins A-D (1-4) and lucidimine E (9), along with seven known aromatic compounds (5-8, 10-12) were isolated from Ganoderma lucidum. Their structures were determined by spectroscopic method. Bioactive evaluation showed that compounds 2-4 and 6-10 displayed remarkable neuroprotective activities against corticosterone-induced PC12 cell damage, with the cell viability ranging from 69.99% to 126.00%; and compounds 1-4, 9 and 10 exhibited significant anti-inflammatory activities against LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, with IC50 values ranging from 4.68 to 15.49 mu M. In particular, compound 10 showed remarkable neuroprotection with EC50 value of 2.49 +/- 0.12 mu M, and potent anti-inflammation with IC50 value of 4.68 +/- 0.09 mu M.
KeywordGanoderma lucidum Aromatic constituents Neuroprotective activity Anti-inflammatory activity Depression
DOI10.1016/j.fitote.2019.01.013
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000468710300008
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/67529
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorQiu, Ming-Hua
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Lu, Shuang-Yang,Peng, Xing-Rong,Dong, Jin-Run,et al. Aromatic constituents from Ganoderma lucidum and their neuroprotective and anti-inflammatory activities[J]. FITOTERAPIA,2019,134:58-64.
APA Lu, Shuang-Yang.,Peng, Xing-Rong.,Dong, Jin-Run.,Yan, Hui.,Kong, Qing-Hua.,...&Qiu, Ming-Hua.(2019).Aromatic constituents from Ganoderma lucidum and their neuroprotective and anti-inflammatory activities.FITOTERAPIA,134,58-64.
MLA Lu, Shuang-Yang,et al."Aromatic constituents from Ganoderma lucidum and their neuroprotective and anti-inflammatory activities".FITOTERAPIA 134(2019):58-64.
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