Dayaolingzhiols A-E, AchE inhibitory meroterpenoids from Ganoderma lucidum

doi:10.1016/j.tet.2019.04.022

	Dayaolingzhiols A-E, AchE inhibitory meroterpenoids from Ganoderma lucidum
	Luo, Qi2,3 ; Yang, Zhu-Liang2 ; Cheng, Yong-Xian 1
通讯作者	Cheng, Yong-Xian(yxcheng@szu.edu.cn)
	2019-05-17
发表期刊	TETRAHEDRON
ISSN	0040-4020
卷号	75 期号:20 页码:2910-2915
摘要	Ganoderma mushrooms are widely used as effective medicines for treating and preventing chronic diseases. In this study, five new meroterpenoids, dayaolingzhiols A (1) and B (2) featuring a 6/6/6 ring system, dayaolingzhiols C-E (3-5) harboring a gamma-lactone motif, along with eight known ones (6-13), were purified from G. lucidum. To clarify their chemical structures, spectroscopic and ECD and OR computational methods were used. In addition, the inhibition of all the new meroterpenoids against AChE was evaluated, disclosing that (+)-4 and (+/-) 5 possess potent AChE inhibitory activities with respective IC50 values of 8.52 +/- 1.90 mu M and 7.37 +/- 0.52 mu M. (C) 2019 Published by Elsevier Ltd.
关键词	Ganoderma lucidum Meroterpenoids Dayaolingzhiols A-E AChE inhibitory activity
DOI	10.1016/j.tet.2019.04.022
收录类别	SCI
语种	英语
WOS记录号	WOS:000468718400007
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/67510
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Cheng, Yong-Xian
作者单位	1.Shenzhen Univ, Sch Pharmaceut Sci, Hlth Sci Ctr, Shenzhen 518060, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Key Lab Plant Divers & Biogeog East Asia, Kunming 650201, Yunnan, Peoples R China 3.Univ Tokyo, Biotechnol Res Ctr, Bunkyo Ku, 1-1-1 Yayoi, Tokyo 1138657, Japan
推荐引用方式 GB/T 7714	Luo, Qi,Yang, Zhu-Liang,Cheng, Yong-Xian. Dayaolingzhiols A-E, AchE inhibitory meroterpenoids from Ganoderma lucidum[J]. TETRAHEDRON,2019,75(20):2910-2915.
APA	Luo, Qi,Yang, Zhu-Liang,&Cheng, Yong-Xian.(2019).Dayaolingzhiols A-E, AchE inhibitory meroterpenoids from Ganoderma lucidum.TETRAHEDRON,75(20),2910-2915.
MLA	Luo, Qi,et al."Dayaolingzhiols A-E, AchE inhibitory meroterpenoids from Ganoderma lucidum".TETRAHEDRON 75.20(2019):2910-2915.

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