Sesquiterpenoids from the roots and rhizomes of Valeriana amurensis and their effects on NGF-induced neurite outgrowth in PC12 cells
Dong, Fa-Wu1; Li, Fang1; Ren, Jia-Jia1; Zhao, Cheng-Mei1; Diao, Hong-Li1; Li, Bao-Jing1; Li, Yan-Ping1; Hu, Jiang-Miao2; He, Hong-Ping1
Corresponding AuthorHu, Jiang-Miao(hujiangmiao@mail.kib.ac.cn) ; He, Hong-Ping(95431111@qq.com)
2019-04-25
Source PublicationNATURAL PRODUCT RESEARCH
ISSN1478-6419
Pages6
AbstractTwo new sesquiterpenoids, including a kessane-type sesquiterpenoid (1) and one bisabolane derivative (2), together with fourteen known sesquiterpenoids (3-16), were isolated from the roots and rhizomes of Valeriana amurensis. The structures of new compounds were established on the basis of extensive spectroscopic analysis. All isolates were evaluated for their effects on nerve growth factor (NGF)-mediated neurite outgrowth in pheochromocytoma (PC12) cells. As a results, four compounds including 10-12 and 15 showed potent promoting effects at the concentration of 10 mu M on NGF-induced neurite outgrowth in PC12 cells with the differentiation rate of 11.84%, 12.21%, 13.77% and 12.16%, respectively. [GRAPHICS] .
KeywordValeriana amurensis sesquiterpenoids central nervous system PC12 cells
DOI10.1080/14786419.2019.1603223
Indexed BySCI
Language英语
WOS IDWOS:000470405900001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/67403
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorHu, Jiang-Miao; He, Hong-Ping
Affiliation1.Yunnan Univ Chinese Med, Coll Tradit Chinese Med, Kunming, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Dong, Fa-Wu,Li, Fang,Ren, Jia-Jia,et al. Sesquiterpenoids from the roots and rhizomes of Valeriana amurensis and their effects on NGF-induced neurite outgrowth in PC12 cells[J]. NATURAL PRODUCT RESEARCH,2019:6.
APA Dong, Fa-Wu.,Li, Fang.,Ren, Jia-Jia.,Zhao, Cheng-Mei.,Diao, Hong-Li.,...&He, Hong-Ping.(2019).Sesquiterpenoids from the roots and rhizomes of Valeriana amurensis and their effects on NGF-induced neurite outgrowth in PC12 cells.NATURAL PRODUCT RESEARCH,6.
MLA Dong, Fa-Wu,et al."Sesquiterpenoids from the roots and rhizomes of Valeriana amurensis and their effects on NGF-induced neurite outgrowth in PC12 cells".NATURAL PRODUCT RESEARCH (2019):6.
Files in This Item: Download All
File Name/Size DocType Version Access License
dong2019.pdf(798KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Dong, Fa-Wu]'s Articles
[Li, Fang]'s Articles
[Ren, Jia-Jia]'s Articles
Baidu academic
Similar articles in Baidu academic
[Dong, Fa-Wu]'s Articles
[Li, Fang]'s Articles
[Ren, Jia-Jia]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Dong, Fa-Wu]'s Articles
[Li, Fang]'s Articles
[Ren, Jia-Jia]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: dong2019.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.