| Sesquiterpenoids from the roots and rhizomes of Valeriana amurensis and their effects on NGF-induced neurite outgrowth in PC12 cells | |
Dong, Fa-Wu1; Li, Fang1; Ren, Jia-Jia1; Zhao, Cheng-Mei1; Diao, Hong-Li1; Li, Bao-Jing1; Li, Yan-Ping1; Hu, Jiang-Miao2 ; He, Hong-Ping1
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| 通讯作者 | Hu, Jiang-Miao(hujiangmiao@mail.kib.ac.cn) ; He, Hong-Ping(95431111@qq.com) |
| 2019-04-25 | |
| 发表期刊 | NATURAL PRODUCT RESEARCH
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| ISSN | 1478-6419 |
| 页码 | 6 |
| 摘要 | Two new sesquiterpenoids, including a kessane-type sesquiterpenoid (1) and one bisabolane derivative (2), together with fourteen known sesquiterpenoids (3-16), were isolated from the roots and rhizomes of Valeriana amurensis. The structures of new compounds were established on the basis of extensive spectroscopic analysis. All isolates were evaluated for their effects on nerve growth factor (NGF)-mediated neurite outgrowth in pheochromocytoma (PC12) cells. As a results, four compounds including 10-12 and 15 showed potent promoting effects at the concentration of 10 mu M on NGF-induced neurite outgrowth in PC12 cells with the differentiation rate of 11.84%, 12.21%, 13.77% and 12.16%, respectively. [GRAPHICS] . |
| 关键词 | Valeriana amurensis sesquiterpenoids central nervous system PC12 cells |
| DOI | 10.1080/14786419.2019.1603223 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000470405900001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/67403 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Hu, Jiang-Miao; He, Hong-Ping |
| 作者单位 | 1.Yunnan Univ Chinese Med, Coll Tradit Chinese Med, Kunming, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Fa-Wu,Li, Fang,Ren, Jia-Jia,et al. Sesquiterpenoids from the roots and rhizomes of Valeriana amurensis and their effects on NGF-induced neurite outgrowth in PC12 cells[J]. NATURAL PRODUCT RESEARCH,2019:6. |
| APA | Dong, Fa-Wu.,Li, Fang.,Ren, Jia-Jia.,Zhao, Cheng-Mei.,Diao, Hong-Li.,...&He, Hong-Ping.(2019).Sesquiterpenoids from the roots and rhizomes of Valeriana amurensis and their effects on NGF-induced neurite outgrowth in PC12 cells.NATURAL PRODUCT RESEARCH,6. |
| MLA | Dong, Fa-Wu,et al."Sesquiterpenoids from the roots and rhizomes of Valeriana amurensis and their effects on NGF-induced neurite outgrowth in PC12 cells".NATURAL PRODUCT RESEARCH (2019):6. |
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