| Acetylcholinesterase inhibitory active metabolites from the endophytic fungus Colletotrichum sp. YMF432 | |
| Li, Zhe1,2; Ma, Ni1,2; Zhao, Pei-Ji1,2 | |
| 通讯作者 | Zhao, Pei-Ji(pjzhao@ynu.edu.cn) |
| 2019-06-18 | |
| 发表期刊 | NATURAL PRODUCT RESEARCH
 |
| ISSN | 1478-6419 |
| 卷号 | 33期号:12页码:1794-1797 |
| 摘要 | An endophytic fungus, Chaetomium sp. YMF432, was isolated from Huperzia serrata (Thunb. ex Murray) Trev. and subjected to phytochemical investigation based on its special environment. From the extracts of fermentation solid of strain YMF 432, eight compounds including 1-O-methylemodin (1), 5-methoxy-2-methyl-3-tricosyl-1,4-benzoquinone (2), 4,8-dihydroxy-1-tetralone (3), (3 beta,5 alpha,6 alpha, 22E)-3-hydroxy-5,6-epoxy-7-one-8(14),22-dien-ergosta (4), ergosta-4,6,8(14),22-tetraen-3-one (5), beta-sitostenone (6), beta-sitosterol (7) and (22E,24R)-ergosta-5,7,22 -trien-3 beta-ol (8) were obtained. Their structures were elucidated on the basis of their spectroscopic data. These compounds were evaluated for acetylcholinesterase inhibitory activities in vitro. Compounds 1, 2, and 4 showed moderate acetylcholinesterase inhibitory activities (IC50 from 37.7 +/- 1.5 to 370.0 +/- 2.9 mu M). [GRAPHICS] . |
| 关键词 | Huperzia serrata endophytic fungus Chaetomium sp YMF 432 metabolites acetylcholinesterase inhibitory |
| DOI | 10.1080/14786419.2018.1434648 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000469988800020 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/67393 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Zhao, Pei-Ji |
| 作者单位 | 1.Yunnan Univ, State Key Lab Conservat & Utilizat Bio Resources, Kunming, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Zhe,Ma, Ni,Zhao, Pei-Ji. Acetylcholinesterase inhibitory active metabolites from the endophytic fungus Colletotrichum sp. YMF432[J]. NATURAL PRODUCT RESEARCH,2019,33(12):1794-1797. |
| APA | Li, Zhe,Ma, Ni,&Zhao, Pei-Ji.(2019).Acetylcholinesterase inhibitory active metabolites from the endophytic fungus Colletotrichum sp. YMF432.NATURAL PRODUCT RESEARCH,33(12),1794-1797. |
| MLA | Li, Zhe,et al."Acetylcholinesterase inhibitory active metabolites from the endophytic fungus Colletotrichum sp. YMF432".NATURAL PRODUCT RESEARCH 33.12(2019):1794-1797. |
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| li2018 (3).pdf（733KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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