| Renoprotective phenolic meroterpenoids from the mushroom Ganoderma cochlear | |
| Wang, Xin-Long2; Wu, Ze-Hong1; Di, Lei2; Zhou, Feng-Jiao2; Yan, Yong-Ming1; Cheng, Yong-Xian1 | |
| 通讯作者 | Cheng, Yong-Xian(yxcheng@szu.edu.cn) |
| 2019-06-01 | |
| 发表期刊 | PHYTOCHEMISTRY
 |
| ISSN | 0031-9422 |
| 卷号 | 162页码:199-206 |
| 摘要 | Twelve previously undescribed phenolic meroterpenoids, cochlearols N-Y, along with two known analogs, ganocochlearins B and C, were isolated from the fruiting bodies of Ganoderma cochlear. Most of these substances were isolated as racemic mixtures. The structures of cochlearols N-Y were assigned based upon spectroscopic data and theoretical calculations. The renoprotective activities of these compounds were evaluated using normal and diseased rat renal interstitial fibroblast cells (NRK-49F). The results show that ganocochlearins S, U, X and Y display potent inhibitory activities against fibronectin overproduction in TGF-beta 1-induced NRK-49F cells. |
| 关键词 | Ganoderma cochlear (Ganodermataceae) Meroterpenoid Calculated ECD Renoprotection |
| DOI | 10.1016/j.phytochem.2019.03.019 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000469157200020 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/67390 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Cheng, Yong-Xian |
| 作者单位 | 1.Shenzhen Univ, Guangdong Key Lab Genome Stabil & Dis Prevent, Sch Pharmaceut Sci, Sch Med,Hlth Sci Ctr, Shenzhen 518060, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xin-Long,Wu, Ze-Hong,Di, Lei,et al. Renoprotective phenolic meroterpenoids from the mushroom Ganoderma cochlear[J]. PHYTOCHEMISTRY,2019,162:199-206. |
| APA | Wang, Xin-Long,Wu, Ze-Hong,Di, Lei,Zhou, Feng-Jiao,Yan, Yong-Ming,&Cheng, Yong-Xian.(2019).Renoprotective phenolic meroterpenoids from the mushroom Ganoderma cochlear.PHYTOCHEMISTRY,162,199-206. |
| MLA | Wang, Xin-Long,et al."Renoprotective phenolic meroterpenoids from the mushroom Ganoderma cochlear".PHYTOCHEMISTRY 162(2019):199-206. |
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| Wang-2019-Renoprotec（1343KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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