New 4,5-seco-20(10 -> 5)-abeo-Abietane Diterpenoids with Anti-Inflammatory Activity from Isodon lophanthoides var. graciliflorus (Benth.) H.Hara
Chen, Wen-Fei1,2,3; Wong, Lai-Lai4; Zhang, Xuan1,2; Zhou, Feng-Xu1,2; Xia, Fan5; Tang, Li-Ping1,2; Li, Xian1,2
Corresponding AuthorXia, Fan(xiafan@mail.kib.ac.cn) ; Tang, Li-Ping() ; Li, Xian(xianlikm@163.com)
2019-06-01
Source PublicationCHEMISTRY & BIODIVERSITY
ISSN1612-1872
Volume16Issue:6Pages:7
AbstractThree new 4,5-seco-20(10 -> 5)-abeo-abietane diterpenoids, 16-hydroxysalvilenone (1), 15-hydroxysalprionin (2), and 11 beta,15-dihydroxysalprionin-12-one (3), and nine known abietane diterpenoids, 4-12, along with one known sempervirane diterpenoid, hispidanol A (13), were isolated from the aerial parts of Isodon lophanthoides var. graciliflorus. The structures of compounds 1-3 were determined on the basis of spectroscopic methods including extensive analysis of NMR and mass spectroscopic data. All diterpenoids were tested for their TNF-alpha inhibitory effects on LPS-induced RAW264.7 cells. Compound 9 (16-acetoxyhorminone) was the most potent with an IC50 value of 3.97 +/- 0.70 mu m.
KeywordIsodon lophanthoides 4 5-seco-20(10 -> 5)-abeo-abietane diterpenoid structure elucidation anti-inflammatory activity biological activity
DOI10.1002/cbdv.201900206
Indexed BySCI
Language英语
WOS IDWOS:000471923800019
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/67241
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorXia, Fan; Tang, Li-Ping; Li, Xian
Affiliation1.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China
2.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China
3.Panzhihua Univ, Affiliated Hosp, Panzhihua 617000, Peoples R China
4.Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Chen, Wen-Fei,Wong, Lai-Lai,Zhang, Xuan,et al. New 4,5-seco-20(10 -> 5)-abeo-Abietane Diterpenoids with Anti-Inflammatory Activity from Isodon lophanthoides var. graciliflorus (Benth.) H.Hara[J]. CHEMISTRY & BIODIVERSITY,2019,16(6):7.
APA Chen, Wen-Fei.,Wong, Lai-Lai.,Zhang, Xuan.,Zhou, Feng-Xu.,Xia, Fan.,...&Li, Xian.(2019).New 4,5-seco-20(10 -> 5)-abeo-Abietane Diterpenoids with Anti-Inflammatory Activity from Isodon lophanthoides var. graciliflorus (Benth.) H.Hara.CHEMISTRY & BIODIVERSITY,16(6),7.
MLA Chen, Wen-Fei,et al."New 4,5-seco-20(10 -> 5)-abeo-Abietane Diterpenoids with Anti-Inflammatory Activity from Isodon lophanthoides var. graciliflorus (Benth.) H.Hara".CHEMISTRY & BIODIVERSITY 16.6(2019):7.
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