| New 4,5-seco-20(10 -> 5)-abeo-Abietane Diterpenoids with Anti-Inflammatory Activity from Isodon lophanthoides var. graciliflorus (Benth.) H.Hara | |
| Chen, Wen-Fei1,2,3; Wong, Lai-Lai4; Zhang, Xuan1,2; Zhou, Feng-Xu1,2; Xia, Fan5; Tang, Li-Ping1,2; Li, Xian1,2 | |
| Corresponding Author | Xia, Fan(xiafan@mail.kib.ac.cn) ; Tang, Li-Ping() ; Li, Xian(xianlikm@163.com) |
| 2019-06-01 | |
| Source Publication | CHEMISTRY & BIODIVERSITY
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| ISSN | 1612-1872 |
| Volume | 16Issue:6Pages:7 |
| Abstract | Three new 4,5-seco-20(10 -> 5)-abeo-abietane diterpenoids, 16-hydroxysalvilenone (1), 15-hydroxysalprionin (2), and 11 beta,15-dihydroxysalprionin-12-one (3), and nine known abietane diterpenoids, 4-12, along with one known sempervirane diterpenoid, hispidanol A (13), were isolated from the aerial parts of Isodon lophanthoides var. graciliflorus. The structures of compounds 1-3 were determined on the basis of spectroscopic methods including extensive analysis of NMR and mass spectroscopic data. All diterpenoids were tested for their TNF-alpha inhibitory effects on LPS-induced RAW264.7 cells. Compound 9 (16-acetoxyhorminone) was the most potent with an IC50 value of 3.97 +/- 0.70 mu m. |
| Keyword | Isodon lophanthoides 4 5-seco-20(10 -> 5)-abeo-abietane diterpenoid structure elucidation anti-inflammatory activity biological activity |
| DOI | 10.1002/cbdv.201900206 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000471923800019 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/67241 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Xia, Fan; Tang, Li-Ping; Li, Xian |
| Affiliation | 1.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China 2.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China 3.Panzhihua Univ, Affiliated Hosp, Panzhihua 617000, Peoples R China 4.Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| Recommended Citation GB/T 7714 | Chen, Wen-Fei,Wong, Lai-Lai,Zhang, Xuan,et al. New 4,5-seco-20(10 -> 5)-abeo-Abietane Diterpenoids with Anti-Inflammatory Activity from Isodon lophanthoides var. graciliflorus (Benth.) H.Hara[J]. CHEMISTRY & BIODIVERSITY,2019,16(6):7. |
| APA | Chen, Wen-Fei.,Wong, Lai-Lai.,Zhang, Xuan.,Zhou, Feng-Xu.,Xia, Fan.,...&Li, Xian.(2019).New 4,5-seco-20(10 -> 5)-abeo-Abietane Diterpenoids with Anti-Inflammatory Activity from Isodon lophanthoides var. graciliflorus (Benth.) H.Hara.CHEMISTRY & BIODIVERSITY,16(6),7. |
| MLA | Chen, Wen-Fei,et al."New 4,5-seco-20(10 -> 5)-abeo-Abietane Diterpenoids with Anti-Inflammatory Activity from Isodon lophanthoides var. graciliflorus (Benth.) H.Hara".CHEMISTRY & BIODIVERSITY 16.6(2019):7. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| chen2019 (3).pdf（319KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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