(+/-) Cochlearoids N-P: three pairs of phenolic meroterpenoids from the fungus Ganoderma cochlear and their bioactivities

doi:10.1080/10286020.2018.1481052

	(+/-) Cochlearoids N-P: three pairs of phenolic meroterpenoids from the fungus Ganoderma cochlear and their bioactivities
	Qin, Fu-Ying 1,2; Yan, Yong-Ming 3; Tu, Zheng-Chao 4; Cheng, Yong-Xian 1,2,3
通讯作者	Cheng, Yong-Xian(yxcheng@szu.edu.cn)
	2019-06-03
发表期刊	JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
ISSN	1028-6020
卷号	21 期号:6 页码:542-550
摘要	Three pairs of meroterpenoids (+/-) cochlearoids N-P (1-3) were isolated from the fruiting bodies of Ganoderma cochlear. Their structures including absolute configurations were assigned by spectroscopic techniques. All the isolated compounds were tested for their inhibitory activities toward BRD4, human cancer cells, and micro-organisms. The results show that the enantiomers of (+/-)-1 are BRD4 inhibitors, (-)-1 and (+)-3 are cytotoxic against human cancer cells (K562) with IC50 values of 7.68 and 6.68 mu M, respectively. Besides compounds (+/-)-2 and (+/-)-3 exhibit potent inhibitory activity against Staphylococcus aureus with IC50 values in the range of 5.43-17.99 mu M. [GRAPHICS] .
关键词	Ganoderma cochlear meroterpenoids BRD4 cytotoxic activity antibacterial activity
DOI	10.1080/10286020.2018.1481052
收录类别	SCI
语种	英语
WOS记录号	WOS:000467401800007
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/66882
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Cheng, Yong-Xian
作者单位	1.Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450008, Henan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Sch Med,Guangdong Key Lab Genome Stabil & Dis Pre, Shenzhen 518060, Peoples R China 4.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Qin, Fu-Ying,Yan, Yong-Ming,Tu, Zheng-Chao,et al. (+/-) Cochlearoids N-P: three pairs of phenolic meroterpenoids from the fungus Ganoderma cochlear and their bioactivities[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2019,21(6):542-550.
APA	Qin, Fu-Ying,Yan, Yong-Ming,Tu, Zheng-Chao,&Cheng, Yong-Xian.(2019).(+/-) Cochlearoids N-P: three pairs of phenolic meroterpenoids from the fungus Ganoderma cochlear and their bioactivities.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,21(6),542-550.
MLA	Qin, Fu-Ying,et al."(+/-) Cochlearoids N-P: three pairs of phenolic meroterpenoids from the fungus Ganoderma cochlear and their bioactivities".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 21.6(2019):542-550.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
qin2018.pdf（1093KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载