Cytotoxic ergosteroids from the fungus Stereum hirsutum
Zhao, Zhen-Zhu1,2,3; Han, Kai-Yue4; Li, Zheng-Hui4; Feng, Tao4; Chen, He-Ping4,5; Liu, Ji-Kai4,5
Corresponding AuthorChen, He-Ping( ; Liu, Ji-Kai(
AbstractPhytochemical investigation on the fermentation broth of the fungus Stereum hirsutum led to the isolation of ten steroids, including two previously unreported ones, namely steresterones A (1) and B (2). The semi-synthesis products 3a and 3b were prepared by reduction of the known compound 3 with NaBH4. Their structures and absolute configurations were established via 1D & 2D NMR spectroscopic analysis, and TDDFT/ECD calculations as well as single crystal X-ray diffraction analysis. The structure of 3 which harbored a 5 beta-H was confirmed by single crystal X-ray diffraction analysis for the first time. All the compounds reported in this study were evaluated for their cytotoxicity against five human cancer cell lines. Bioassay results revealed that 3, 4, 6-9 displayed significant anti-proliferative effects with IC50 values varying from 2.3 to 34.3 mu M. The structure-activity relationships of 3, 3a, 3b were discussed.
KeywordStereum hirsutum Steroids Semi-synthesis Cytotoxicity
Indexed BySCI
WOS IDWOS:000461363900028
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Document Type期刊论文
Corresponding AuthorChen, He-Ping; Liu, Ji-Kai
Affiliation1.Henan Univ Chinese Med, Collaborat Innovat Ctr Resp Dis Diag & Treatment, Zhengshou 450046, Peoples R China
2.Henan Univ Chinese Med, Chinese Med Dev Henan Prov, Zhengshou 450046, Peoples R China
3.Henan Univ Chinese Med, Sch Pharm, Zhengsshou 450046, Peoples R China
4.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
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GB/T 7714
Zhao, Zhen-Zhu,Han, Kai-Yue,Li, Zheng-Hui,et al. Cytotoxic ergosteroids from the fungus Stereum hirsutum[J]. PHYTOCHEMISTRY LETTERS,2019,30:143-149.
APA Zhao, Zhen-Zhu,Han, Kai-Yue,Li, Zheng-Hui,Feng, Tao,Chen, He-Ping,&Liu, Ji-Kai.(2019).Cytotoxic ergosteroids from the fungus Stereum hirsutum.PHYTOCHEMISTRY LETTERS,30,143-149.
MLA Zhao, Zhen-Zhu,et al."Cytotoxic ergosteroids from the fungus Stereum hirsutum".PHYTOCHEMISTRY LETTERS 30(2019):143-149.
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