Garsubelone A, the First Dimeric Polycyclic Polyprenylated Acylphloroglucinols with Complicated Heptacyclic Architecture from Garcinia subelliptica
Wang, Yong-Ling1,2; Ye, Yan-Song3,4,5; Fu, Wen-Wei1,2; Wu, Rong1,2; Xiang, Qian1,2; Lao, Yuan-Zhi1,2; Yang, Jin-Ling1,2; Tan, Hong-Sheng1,2; Yang, Xing-Wei3,4; Yang, Bai-Can1,2; Xu, Hong-Xi1,2; Xu, Gang3,4
Corresponding AuthorXu, Hong-Xi(xugang008@mail.kib.ac.cn) ; Xu, Gang(xuhongxi88@gmail.com)
2019-03-01
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume21Issue:5Pages:1534-1537
AbstractGarsubelone A (1), the first dimeric polycyclic polyprenylated acylphloroglucinols type metabolite featuring a complicated 6/6/6/6/6/6/6 heptacyclic architecture containing 10 stereogenic centers, was isolated from Garcinia subelliptica. Biogenetically, this compound was constructed by the plausible monomeric precursor, garsubelone B (2) and secohyperforin, via a key Diels-Alder cycloaddition to form an unique 2-oxabicyclo[3.3.1]nonane core. Their structures and absolute configurations were determined by comprehensive spectroscopic and X-ray diffraction techniques. The cytotoxic activities of these isolates were also evaluated.
DOI10.1021/acs.orglett.9b00388
Indexed BySCI
Language英语
WOS IDWOS:000460491700063
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/64994
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorXu, Hong-Xi; Xu, Gang
Affiliation1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
2.Shanghai Coll TCM New Drug Discovery, Engn Res Ctr, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
4.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Wang, Yong-Ling,Ye, Yan-Song,Fu, Wen-Wei,et al. Garsubelone A, the First Dimeric Polycyclic Polyprenylated Acylphloroglucinols with Complicated Heptacyclic Architecture from Garcinia subelliptica[J]. ORGANIC LETTERS,2019,21(5):1534-1537.
APA Wang, Yong-Ling.,Ye, Yan-Song.,Fu, Wen-Wei.,Wu, Rong.,Xiang, Qian.,...&Xu, Gang.(2019).Garsubelone A, the First Dimeric Polycyclic Polyprenylated Acylphloroglucinols with Complicated Heptacyclic Architecture from Garcinia subelliptica.ORGANIC LETTERS,21(5),1534-1537.
MLA Wang, Yong-Ling,et al."Garsubelone A, the First Dimeric Polycyclic Polyprenylated Acylphloroglucinols with Complicated Heptacyclic Architecture from Garcinia subelliptica".ORGANIC LETTERS 21.5(2019):1534-1537.
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