Difengpienols A and B, two new sesqui-neolignans with anti-inflammatory activity from the bark of Illicium difengpi
Pan, Zheng-Hong1; Cheng, Ling1; Ning, De-Sheng1; Peng, Li-Yan2; Fu, Yu-Xia1; Li, Lian-Chun1
Corresponding AuthorPan, Zheng-Hong(pan7260@126.com)
2019-04-01
Source PublicationPHYTOCHEMISTRY LETTERS
ISSN1874-3900
Volume30Pages:210-214
AbstractAs part of our ongoing search for novel and bioactive natural products in Karst plants, two new sesqui-neolignans, difengpienol A (1) and difengpienol B (2), together with two known analogues (3 and 4), were isolated from the stem bark of Illicium difengpi. Their structures were elucidated by analysis of spectroscopic data. Difengpienol A (1) possessed a unique 1, 4-dibenzodioxocine moiety. All isolates were evaluated for inhibitory effects against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages cells. Compounds 1 and 2 showed moderate inhibitory effects on NO production with IC50 values of 16.9 and 23.8 mu M. A biosynthetic pathway was also proposed for 1 and 2.
KeywordIllicium difengpi Difengpienol A Difengpienol B Sesqui-neolignans Anti-inflammatory
DOI10.1016/j.phytol.2019.02.023
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal
WOS IDWOS:000461363900042
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/64985
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorPan, Zheng-Hong
Affiliation1.Chinese Acad Sci, Guangxi Inst Bot, Guangxi Key Lab Funct Phytochem Res & Utilizat, Guilin 541006, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Pan, Zheng-Hong,Cheng, Ling,Ning, De-Sheng,et al. Difengpienols A and B, two new sesqui-neolignans with anti-inflammatory activity from the bark of Illicium difengpi[J]. PHYTOCHEMISTRY LETTERS,2019,30:210-214.
APA Pan, Zheng-Hong,Cheng, Ling,Ning, De-Sheng,Peng, Li-Yan,Fu, Yu-Xia,&Li, Lian-Chun.(2019).Difengpienols A and B, two new sesqui-neolignans with anti-inflammatory activity from the bark of Illicium difengpi.PHYTOCHEMISTRY LETTERS,30,210-214.
MLA Pan, Zheng-Hong,et al."Difengpienols A and B, two new sesqui-neolignans with anti-inflammatory activity from the bark of Illicium difengpi".PHYTOCHEMISTRY LETTERS 30(2019):210-214.
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