Panaxadiol and panaxatriol derivatives as anti-hepatitis B virus inhibitors.

	Panaxadiol and panaxatriol derivatives as anti-hepatitis B virus inhibitors.
	Chen, Hao; Wang, Li-Jun; Ma, Yun-Bao; Huang, Xiao-Yan; Geng, Chang-An; Zhang, Xue-Mei; Chen, Ji-Jun
	2014
发表期刊	Natural products and bioprospecting
ISSN	2192-2195
卷号	4 期号:3 页码:163-74
摘要	ABSTRACT: 28 Derivatives of panaxadiol (PD) and panaxatriol were synthesized and evaluated for their anti-HBV activity on HepG 2.2.15 cells, of which 17 derivatives inhibited HBV DNA replication. Compounds 4, 9, 10, 14, and 15 showed moderate activity against HBV DNA replication with IC50 values ranged from 7.27 to 28.21muM compared with PD. In particular, 3-O-2'-thenoyl panaxadiol (4) inhibited not only HBV DNA replication (IC50=16.5muM, SI >115.7) but also HBsAg (IC50=30.8muM, SI >62.0) and HBeAg (IC50=18.2muM, SI >105.14) secretions. Their structure-activity relationships were discussed for guiding future research toward the discovery of new anti-HBV agents.
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64919
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Chen, Hao,Wang, Li-Jun,Ma, Yun-Bao,et al. Panaxadiol and panaxatriol derivatives as anti-hepatitis B virus inhibitors.[J]. Natural products and bioprospecting,2014,4(3):163-74.
APA	Chen, Hao.,Wang, Li-Jun.,Ma, Yun-Bao.,Huang, Xiao-Yan.,Geng, Chang-An.,...&Chen, Ji-Jun.(2014).Panaxadiol and panaxatriol derivatives as anti-hepatitis B virus inhibitors..Natural products and bioprospecting,4(3),163-74.
MLA	Chen, Hao,et al."Panaxadiol and panaxatriol derivatives as anti-hepatitis B virus inhibitors.".Natural products and bioprospecting 4.3(2014):163-74.