Panaxadiol and panaxatriol derivatives as anti-hepatitis B virus inhibitors.
Chen, Hao; Wang, Li-Jun; Ma, Yun-Bao; Huang, Xiao-Yan; Geng, Chang-An; Zhang, Xue-Mei; Chen, Ji-Jun
2014
Source PublicationNatural products and bioprospecting
ISSN2192-2195
Volume4Issue:3Pages:163-74
AbstractABSTRACT: 28 Derivatives of panaxadiol (PD) and panaxatriol were synthesized and evaluated for their anti-HBV activity on HepG 2.2.15 cells, of which 17 derivatives inhibited HBV DNA replication. Compounds 4, 9, 10, 14, and 15 showed moderate activity against HBV DNA replication with IC50 values ranged from 7.27 to 28.21muM compared with PD. In particular, 3-O-2'-thenoyl panaxadiol (4) inhibited not only HBV DNA replication (IC50=16.5muM, SI >115.7) but also HBsAg (IC50=30.8muM, SI >62.0) and HBeAg (IC50=18.2muM, SI >105.14) secretions. Their structure-activity relationships were discussed for guiding future research toward the discovery of new anti-HBV agents.
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/64919
Collection植物化学与西部植物资源持续利用国家重点实验室
Recommended Citation
GB/T 7714
Chen, Hao,Wang, Li-Jun,Ma, Yun-Bao,et al. Panaxadiol and panaxatriol derivatives as anti-hepatitis B virus inhibitors.[J]. Natural products and bioprospecting,2014,4(3):163-74.
APA Chen, Hao.,Wang, Li-Jun.,Ma, Yun-Bao.,Huang, Xiao-Yan.,Geng, Chang-An.,...&Chen, Ji-Jun.(2014).Panaxadiol and panaxatriol derivatives as anti-hepatitis B virus inhibitors..Natural products and bioprospecting,4(3),163-74.
MLA Chen, Hao,et al."Panaxadiol and panaxatriol derivatives as anti-hepatitis B virus inhibitors.".Natural products and bioprospecting 4.3(2014):163-74.
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