Effects of Traditional Chinese Medicinal Plants on Anti-insulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells.

	Effects of Traditional Chinese Medicinal Plants on Anti-insulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells.
	Ma, Jun-Zeng; Yang, Li-Xin; Shen, Xiao-Ling; Qin, Ji-Huan; Deng, Li-Lan; Ahmed, Selena; Xu, Hong-Xi; Xue, Da-Yuan; Ye, Jiang-Xia; Xu, Gang
	2014
Source Publication	Natural products and bioprospecting
ISSN	2192-2195
Volume	4 Issue:4 Pages:197-206
Abstract	ABSTRACT: Medicinal plants have a long history of use in China to treat diabetic symptoms. Ancient Chinese medical manuscripts and ethnobotanical surveys document plant remedies that continue to be actively used in China for the treatment of diabetic symptoms. Based on a systematic ancient Chinese medical manuscripts review in combination with ethnobotanical survey, 16 medicinal plants for the traditional treatment of diabetic symptoms were identified for the evaluation of anti-insulin resistance bioactivity. The biological activity of 16 medicinal plants was tested on dexamethasone (DXMS)-induced insulin resistant HepG2 cells. The result shows that 11 of the 16 medicinal plants enhanced glucose uptake of DXMS-induced insulin resistant HepG2 cells, thereby demonstrating their ability to increase insulin sensitivity, other five medicinal plants including Astragalus membranaceus were found ineffective. The study shows that ancient Chinese medical manuscripts and ethnobotanical surveys on plants for the prevention and treatment of diabetic symptoms provide a promising knowledge base for drug discovery to mitigate the global diabetes epidemic.
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/64911
Collection	植物化学与西部植物资源持续利用国家重点实验室
Recommended Citation GB/T 7714	Ma, Jun-Zeng,Yang, Li-Xin,Shen, Xiao-Ling,et al. Effects of Traditional Chinese Medicinal Plants on Anti-insulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells.[J]. Natural products and bioprospecting,2014,4(4):197-206.
APA	Ma, Jun-Zeng.,Yang, Li-Xin.,Shen, Xiao-Ling.,Qin, Ji-Huan.,Deng, Li-Lan.,...&Xu, Gang.(2014).Effects of Traditional Chinese Medicinal Plants on Anti-insulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells..Natural products and bioprospecting,4(4),197-206.
MLA	Ma, Jun-Zeng,et al."Effects of Traditional Chinese Medicinal Plants on Anti-insulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells.".Natural products and bioprospecting 4.4(2014):197-206.

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