The Lifespan-Promoting Effect of Otophylloside B in Caenorhabditis elegans.

	The Lifespan-Promoting Effect of Otophylloside B in Caenorhabditis elegans.
	Yang, Jie; Wan, Qin-Li; Mu, Quan-Zhang; Wu, Chun-Feng; Ding, Ai-Jun; Yang, Zhong-Lin; Qiu, Ming-Hua; Luo, Huai-Rong
	2015
发表期刊	Natural products and bioprospecting
ISSN	2192-2195
卷号	5 期号:4 页码:177-183
摘要	Aging is the major risk factor for many human diseases and degeneration. Thus, clinically effective medicine could delay the process of aging and aging-related diseases are desperately wanted. In traditional Chinese medicine (TCM), some were claimed to slow down aging. Qingyangshen (Cynanchum otophyllum schneid) is such a TCM. Here, we assayed the longevity effect of compound Otophylloside B (Ot B), a C-21 steroidal glycoside isolated from Qingyangshen, in Caenorhabditis elegans, which is a popular model for aging research. Our results showed that Ot B could modestly extend the lifespan of C. elegans, delay the age-related decline of body movement and improve the stress resistance. Further investigating the molecular mechanism of lifespan extension effect revealed that Ot B could activate the FOXO transcription factor DAF-16. Ot B could not further extend the lifespan of long-lived mutant of insulin/IGF-1-like receptor (daf-2). In addition, Ot B also requires SIR-2.1 and CLK-1 which is an enzyme in ubiquinone synthesis, for lifespan extension.
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64902
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Yang, Jie,Wan, Qin-Li,Mu, Quan-Zhang,et al. The Lifespan-Promoting Effect of Otophylloside B in Caenorhabditis elegans.[J]. Natural products and bioprospecting,2015,5(4):177-183.
APA	Yang, Jie.,Wan, Qin-Li.,Mu, Quan-Zhang.,Wu, Chun-Feng.,Ding, Ai-Jun.,...&Luo, Huai-Rong.(2015).The Lifespan-Promoting Effect of Otophylloside B in Caenorhabditis elegans..Natural products and bioprospecting,5(4),177-183.
MLA	Yang, Jie,et al."The Lifespan-Promoting Effect of Otophylloside B in Caenorhabditis elegans.".Natural products and bioprospecting 5.4(2015):177-183.