Otophylloside B Protects Against Abeta Toxicity in Caenorhabditis elegans Models of Alzheimer's Disease.
Yang, Jie; Huang, Xiao-Bing; Wan, Qin-Li; Ding, Ai-Jun; Yang, Zhong-Lin; Qiu, Ming-Hua; Sun, Hua-Ying; Qi, Shu-Hua; Luo, Huai-Rong
2017
Source PublicationNatural products and bioprospecting
ISSN2192-2195
Volume7Issue:2Pages:207-214
AbstractAlzheimer's disease (AD) is a major public health concern worldwide and the few drugs currently available only treat the symptoms. Hence, there is a strong need to find more effective anti-AD agents. Cynanchum otophyllum is a traditional Chinese medicine for treating epilepsy, and otophylloside B (Ot B), isolated from C. otophyllum, is the essential active component. Having previously identified anti-aging effects of Ot B, we evaluated Ot B for AD prevention in C. elegans models of AD and found that Ot B extended lifespan, increased heat stress-resistance, delayed body paralysis, and increased the chemotaxis response. Collectively, these results indicated that Ot B protects against Abeta toxicity. Further mechanistic studies revealed that Ot B decreased Abeta deposition by decreasing the expression of Abeta at the mRNA level. Genetic analyses showed that Ot B mediated its effects by increasing the activity of heat shock transcription factor (HSF) by upregulating the expression of hsf-1 and its target genes, hsp-12.6, hsp-16.2 and hsp-70. Ot B also increased the expression of sod-3 by partially activating DAF-16, while SKN-1 was not essential in Ot B-mediated protection against Abeta toxicity.
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/64851
Collection植物化学与西部植物资源持续利用国家重点实验室
Recommended Citation
GB/T 7714
Yang, Jie,Huang, Xiao-Bing,Wan, Qin-Li,et al. Otophylloside B Protects Against Abeta Toxicity in Caenorhabditis elegans Models of Alzheimer's Disease.[J]. Natural products and bioprospecting,2017,7(2):207-214.
APA Yang, Jie.,Huang, Xiao-Bing.,Wan, Qin-Li.,Ding, Ai-Jun.,Yang, Zhong-Lin.,...&Luo, Huai-Rong.(2017).Otophylloside B Protects Against Abeta Toxicity in Caenorhabditis elegans Models of Alzheimer's Disease..Natural products and bioprospecting,7(2),207-214.
MLA Yang, Jie,et al."Otophylloside B Protects Against Abeta Toxicity in Caenorhabditis elegans Models of Alzheimer's Disease.".Natural products and bioprospecting 7.2(2017):207-214.
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