Otophylloside B Protects Against Abeta Toxicity in Caenorhabditis elegans Models of Alzheimer's Disease.

	Otophylloside B Protects Against Abeta Toxicity in Caenorhabditis elegans Models of Alzheimer's Disease.
	Yang, Jie; Huang, Xiao-Bing; Wan, Qin-Li; Ding, Ai-Jun; Yang, Zhong-Lin; Qiu, Ming-Hua; Sun, Hua-Ying; Qi, Shu-Hua; Luo, Huai-Rong
	2017
发表期刊	Natural products and bioprospecting
ISSN	2192-2195
卷号	7 期号:2 页码:207-214
摘要	Alzheimer's disease (AD) is a major public health concern worldwide and the few drugs currently available only treat the symptoms. Hence, there is a strong need to find more effective anti-AD agents. Cynanchum otophyllum is a traditional Chinese medicine for treating epilepsy, and otophylloside B (Ot B), isolated from C. otophyllum, is the essential active component. Having previously identified anti-aging effects of Ot B, we evaluated Ot B for AD prevention in C. elegans models of AD and found that Ot B extended lifespan, increased heat stress-resistance, delayed body paralysis, and increased the chemotaxis response. Collectively, these results indicated that Ot B protects against Abeta toxicity. Further mechanistic studies revealed that Ot B decreased Abeta deposition by decreasing the expression of Abeta at the mRNA level. Genetic analyses showed that Ot B mediated its effects by increasing the activity of heat shock transcription factor (HSF) by upregulating the expression of hsf-1 and its target genes, hsp-12.6, hsp-16.2 and hsp-70. Ot B also increased the expression of sod-3 by partially activating DAF-16, while SKN-1 was not essential in Ot B-mediated protection against Abeta toxicity.
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64851
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Yang, Jie,Huang, Xiao-Bing,Wan, Qin-Li,et al. Otophylloside B Protects Against Abeta Toxicity in Caenorhabditis elegans Models of Alzheimer's Disease.[J]. Natural products and bioprospecting,2017,7(2):207-214.
APA	Yang, Jie.,Huang, Xiao-Bing.,Wan, Qin-Li.,Ding, Ai-Jun.,Yang, Zhong-Lin.,...&Luo, Huai-Rong.(2017).Otophylloside B Protects Against Abeta Toxicity in Caenorhabditis elegans Models of Alzheimer's Disease..Natural products and bioprospecting,7(2),207-214.
MLA	Yang, Jie,et al."Otophylloside B Protects Against Abeta Toxicity in Caenorhabditis elegans Models of Alzheimer's Disease.".Natural products and bioprospecting 7.2(2017):207-214.