Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla.

	Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla.
	Wei, Xin; Jiang, Li-Ping; Guo, Ying; Khan, Afsar; Liu, Ya-Ping; Yu, Hao-Fei; Wang, Bei; Ding, Cai-Feng; Zhu, Pei-Feng; Chen, Ying-Ying; Zhao, Yun-Li; Chen, Yong-Bing; Wang, Yi-Fen; Luo, Xiao-Dong
	2017
发表期刊	Natural products and bioprospecting
ISSN	2192-2195
卷号	7 期号:5 页码:413-419
摘要	Uncaria rhynchophylla is commonly recognized as a traditional treatment for dizziness, cerebrovascular diseases, and nervous disorders in China. Previously, the neuro-protective activities of the alkaloids from U. rhynchophylla were intensively reported. In current work, three new indole alkaloids (1-3), identified as geissoschizic acid (1), geissoschizic acid N 4-oxide (2), and 3beta-sitsirikine N 4-oxide (3), as well as 26 known analogues were isolated from U. rhynchophylla. However, in the neural stem cells (NSCs) proliferation assay for all isolated compounds, geissoschizic acid (1), geissoschizic acid N 4-oxide (2), isocorynoxeine (6), isorhynchophylline (7), (4S)-akuammigine N-oxide (8), and (4S)-rhynchophylline N-oxide (10) showed unexpected inhibitory activities at 10muM. Unlike previous neuro-protective reports, as a warning or caution, our finding showcased a clue for possible NSCs toxicity and the neural lesions risk of U. rhynchophylla, while the structure-activity relationships of the isolated compounds were discussed also.
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64831
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Wei, Xin,Jiang, Li-Ping,Guo, Ying,et al. Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla.[J]. Natural products and bioprospecting,2017,7(5):413-419.
APA	Wei, Xin.,Jiang, Li-Ping.,Guo, Ying.,Khan, Afsar.,Liu, Ya-Ping.,...&Luo, Xiao-Dong.(2017).Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla..Natural products and bioprospecting,7(5),413-419.
MLA	Wei, Xin,et al."Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla.".Natural products and bioprospecting 7.5(2017):413-419.