Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla.
Wei, Xin; Jiang, Li-Ping; Guo, Ying; Khan, Afsar; Liu, Ya-Ping; Yu, Hao-Fei; Wang, Bei; Ding, Cai-Feng; Zhu, Pei-Feng; Chen, Ying-Ying; Zhao, Yun-Li; Chen, Yong-Bing; Wang, Yi-Fen; Luo, Xiao-Dong
2017
Source PublicationNatural products and bioprospecting
ISSN2192-2195
Volume7Issue:5Pages:413-419
AbstractUncaria rhynchophylla is commonly recognized as a traditional treatment for dizziness, cerebrovascular diseases, and nervous disorders in China. Previously, the neuro-protective activities of the alkaloids from U. rhynchophylla were intensively reported. In current work, three new indole alkaloids (1-3), identified as geissoschizic acid (1), geissoschizic acid N 4-oxide (2), and 3beta-sitsirikine N 4-oxide (3), as well as 26 known analogues were isolated from U. rhynchophylla. However, in the neural stem cells (NSCs) proliferation assay for all isolated compounds, geissoschizic acid (1), geissoschizic acid N 4-oxide (2), isocorynoxeine (6), isorhynchophylline (7), (4S)-akuammigine N-oxide (8), and (4S)-rhynchophylline N-oxide (10) showed unexpected inhibitory activities at 10muM. Unlike previous neuro-protective reports, as a warning or caution, our finding showcased a clue for possible NSCs toxicity and the neural lesions risk of U. rhynchophylla, while the structure-activity relationships of the isolated compounds were discussed also.
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/64831
Collection植物化学与西部植物资源持续利用国家重点实验室
Recommended Citation
GB/T 7714
Wei, Xin,Jiang, Li-Ping,Guo, Ying,et al. Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla.[J]. Natural products and bioprospecting,2017,7(5):413-419.
APA Wei, Xin.,Jiang, Li-Ping.,Guo, Ying.,Khan, Afsar.,Liu, Ya-Ping.,...&Luo, Xiao-Dong.(2017).Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla..Natural products and bioprospecting,7(5),413-419.
MLA Wei, Xin,et al."Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla.".Natural products and bioprospecting 7.5(2017):413-419.
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