Antitumor Research on Artemisinin and Its Bioactive Derivatives.

KIB OpenIR

	Antitumor Research on Artemisinin and Its Bioactive Derivatives.
	Zhang, Yunqin; Xu, Guowei; Zhang, Shuqun; Wang, Dong; Saravana Prabha, P; Zuo, Zhili
	2018
发表期刊	Natural products and bioprospecting
ISSN	2192-2195
卷号	8 期号:4 页码:303-319
摘要	Cancer is the leading cause of human death which seriously threatens human life. The antimalarial drug artemisinin and its derivatives have been discovered with considerable anticancer properties. Simultaneously, a variety of target-selective artemisinin-related compounds with high efficiency have been discovered. Many researches indicated that artemisinin-related compounds have cytotoxic effects against a variety of cancer cells through pleiotropic effects, including inhibiting the proliferation of tumor cells, promoting apoptosis, inducing cell cycle arrest, disrupting cancer invasion and metastasis, preventing angiogenesis, mediating the tumor-related signaling pathways, and regulating tumor microenvironment. More importantly, artemisinins demonstrated minor side effects to normal cells and manifested the ability to overcome multidrug-resistance which is widely observed in cancer patients. Therefore, we concentrated on the new advances and development of artemisinin and its derivatives as potential antitumor agents in recent 5years. It is our hope that this review could be helpful for further exploration of novel artemisinin-related antitumor agents.
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64805
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Zhang, Yunqin,Xu, Guowei,Zhang, Shuqun,et al. Antitumor Research on Artemisinin and Its Bioactive Derivatives.[J]. Natural products and bioprospecting,2018,8(4):303-319.
APA	Zhang, Yunqin,Xu, Guowei,Zhang, Shuqun,Wang, Dong,Saravana Prabha, P,&Zuo, Zhili.(2018).Antitumor Research on Artemisinin and Its Bioactive Derivatives..Natural products and bioprospecting,8(4),303-319.
MLA	Zhang, Yunqin,et al."Antitumor Research on Artemisinin and Its Bioactive Derivatives.".Natural products and bioprospecting 8.4(2018):303-319.