Autocatalytic synthesis of 3-ethyl-3-hydroxy-indole-2-ones and their neuroprotection and antitumor activities' evaluation

doi:10.1016/j.crci.2018.02.009

KIB OpenIR

	Autocatalytic synthesis of 3-ethyl-3-hydroxy-indole-2-ones and their neuroprotection and antitumor activities' evaluation
	Chen, Gang; Lin, Jiao; Zhang, Jie; Wu, Ya; Gu, Xuefan; Hao, Xiaojiang; Zhang, Yu
通讯作者	Chen, Gang(gangchen@xsyu.edu.cn) ; Hao, Xiaojiang(xjhao@mail.kib.ac.cn)
	2018
发表期刊	COMPTES RENDUS CHIMIE
ISSN	1631-0748
卷号	21 期号:5 页码:471-474
摘要	In this study, a series of 3-ethyl-3-hydroxy-indole-2-ones were synthesized through the addition reaction of Et2Zn and N -substituted isatin by an autocatalytic process. The synthesized compounds were characterized by NMR spectroscopy and mass spectrometry, and the reaction mechanism was discussed. The antitumor and neuroprotection activities of these compounds were evaluated. The results showed that several compounds display protection activity on H2O2-induced apoptosis of PC12 cells, which are more effective than that of (+/-)-alpha-tocopherol Vitamin E (VE). Moreover, these compounds also show antitumor activity against A549 and P388 cell lines. (C) 2018 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.
关键词	Isatin 3-Ethyl-3-hydroxy-indole-2-one Antitumor Neuroprotection
DOI	10.1016/j.crci.2018.02.009
收录类别	SCI ; SCI
语种	英语
WOS记录号	WOS:000439254800001
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64766
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Chen, Gang,Lin, Jiao,Zhang, Jie,et al. Autocatalytic synthesis of 3-ethyl-3-hydroxy-indole-2-ones and their neuroprotection and antitumor activities' evaluation[J]. COMPTES RENDUS CHIMIE,2018,21(5):471-474.
APA	Chen, Gang.,Lin, Jiao.,Zhang, Jie.,Wu, Ya.,Gu, Xuefan.,...&Zhang, Yu.(2018).Autocatalytic synthesis of 3-ethyl-3-hydroxy-indole-2-ones and their neuroprotection and antitumor activities' evaluation.COMPTES RENDUS CHIMIE,21(5),471-474.
MLA	Chen, Gang,et al."Autocatalytic synthesis of 3-ethyl-3-hydroxy-indole-2-ones and their neuroprotection and antitumor activities' evaluation".COMPTES RENDUS CHIMIE 21.5(2018):471-474.