Neo-clerodane and abietane diterpenoids with neurotrophic activities from the aerial parts of Salvia leucantha Cav.

KIB OpenIR

	Neo-clerodane and abietane diterpenoids with neurotrophic activities from the aerial parts of Salvia leucantha Cav.
	Li, Lai-Wei; Qi, Yan-Yan; Liu, Shi-Xi; Wu, Xing-De; Zhao, Qin-Shi
	2018
发表期刊	FITOTERAPIA
ISSN	0367-326X
卷号	127 页码:367-374
摘要	Four new neoclerodane diterpenoids, leucansalvialins F-I (1 4), and one rare 18(4 3)-abeo-abietane diterpenoid, leucansalvialin J (5), were isolated from the aerial part of Salvia leucantha Cav., along with 14 known analogues. Leucansalvialin F (1) represents the first rearranged salvigenane type clerodane-17,12:18,6-diolide. Their structures were elucidated by 1D and 2D NMR spectroscopic data analysis, and the absolute configurations of 1, 2, 3, and 5 were determinded by X-ray diffraction crystal analysis and the ECD technique. All of the isolated components were evaluated for their neurotrophic activities on PC12 cells and all new compounds were evaluated for their cytotoxicity against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW480). Compounds 2 and 5 showed moderate neuroprotective effects in an in vitro assay.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64734
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Li, Lai-Wei,Qi, Yan-Yan,Liu, Shi-Xi,et al. Neo-clerodane and abietane diterpenoids with neurotrophic activities from the aerial parts of Salvia leucantha Cav.[J]. FITOTERAPIA,2018,127:367-374.
APA	Li, Lai-Wei,Qi, Yan-Yan,Liu, Shi-Xi,Wu, Xing-De,&Zhao, Qin-Shi.(2018).Neo-clerodane and abietane diterpenoids with neurotrophic activities from the aerial parts of Salvia leucantha Cav..FITOTERAPIA,127,367-374.
MLA	Li, Lai-Wei,et al."Neo-clerodane and abietane diterpenoids with neurotrophic activities from the aerial parts of Salvia leucantha Cav.".FITOTERAPIA 127(2018):367-374.