Natural cyclopeptide RA-V inhibits the NF-kappa B signaling pathway by targeting TAK1

KIB OpenIR

	Natural cyclopeptide RA-V inhibits the NF-kappa B signaling pathway by targeting TAK1
	Wang, Zhe; Zhao, Simeng; Song, Lihua; Pu, Yuzhi; Wang, Qiang; Zeng, Guangzhi; Liu, Xing; Bai, Ming; Li, Shao; Gao, Fabao; Chen, Lijuan; Wang, Chen; Tan, Ninghua
	2018
发表期刊	CELL DEATH & DISEASE
ISSN	2041-4889
卷号	9 页码:715
摘要	Rubiaceae-type cyclopeptides (RAs) are a type of plant cyclopeptides from the Rubia that have garnered significant attention owing to their unique bicyclic structures and amazing antitumour activities. Our recent work has shown that RAs suppress inflammation and angiogenesis and induce apoptosis. However, the underlying mechanism and targets remained unknown. Nuclear factor kappa B (NF-kappa B) signaling pathway plays a critical role in these biological processes, prompting us to investigate whether and how RAs affect this pathway. By screening compound libraries using NF-kappa B-dependent luciferase reporter, we observed that RA-V is the best NF-kappa B inhibitor. Further experiments demonstrated that RA-V interrupted the TAK1-TAB2 interaction and targeted TAK1 in this pathway. Moreover, RA-V prevented endotoxin shock and inhibited NF-kappa B activation and tumor growth in vivo. These findings clarify the mechanism of RAV on NF-kappa B pathway and might account for the majority of known bioactivities of RA-V, which will help RA-V develop as new antiinflammatory and antitumour therapies.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64729
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Wang, Zhe,Zhao, Simeng,Song, Lihua,et al. Natural cyclopeptide RA-V inhibits the NF-kappa B signaling pathway by targeting TAK1[J]. CELL DEATH & DISEASE,2018,9:715.
APA	Wang, Zhe.,Zhao, Simeng.,Song, Lihua.,Pu, Yuzhi.,Wang, Qiang.,...&Tan, Ninghua.(2018).Natural cyclopeptide RA-V inhibits the NF-kappa B signaling pathway by targeting TAK1.CELL DEATH & DISEASE,9,715.
MLA	Wang, Zhe,et al."Natural cyclopeptide RA-V inhibits the NF-kappa B signaling pathway by targeting TAK1".CELL DEATH & DISEASE 9(2018):715.