Vibsanin A sensitizes human acute myeloid leukemia cells to tyrosine kinase inhibitor-induced myeloid differentiation via activation of PKC and upregulation of Lyn

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	Vibsanin A sensitizes human acute myeloid leukemia cells to tyrosine kinase inhibitor-induced myeloid differentiation via activation of PKC and upregulation of Lyn
	Shen, Xing; Xing, Shuang; Zhang, Lu; Wang, Fangmin; Ou, Hongling; Shan, Yajun; Xiao, He; Xiang, Guolin; Wang, Xinru; Zhao, Qinshi; Cong, Yuwen; Yu, Zuyin
	2018
发表期刊	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN	0006-291X
卷号	502 期号:1 页码:110-115
摘要	Differentiation therapies have been proposed to overcome the impaired cell differentiation in acute myeloid leukemia (AML). However, thus far the all-trans retinoic acid-based differentiation therapy has been the only successful modality in treating acute promyelocytic leukemia. Here, we showed that vibsanin A, a novel protein kinase C (PKC) activator, sensitized AML cells to tyrosine kinase inhibitor (TKI)-induced differentiation. Vibsanin A augmented the ability of TKIs to induce growth inhibition and Cl cell cycle arrest of AML cells. Mechanistically, PKC activation was involved in the differentiation-inducing effects of combining vibsanin A with TKIs. Moreover, we found that vibsanin A enhanced TKI-induced Lyn expression and suppression of Lyn interfered with AML cell differentiation, indicating an essential role for Lyn expression in the combination-induced differentiation. Finally, combining vibsanin A and TKIs enhanced the activation of the Raf/MEK/ERK cascade. Together, this is the first study to evaluate the synergy of vibsanin A and TKIs in AML cell differentiation. Our study lays the foundation in assessing new opportunities for the combination of vibsanin A and TKIs as a promising approach for future differentiation therapy. (C) 2018 Elsevier Inc. All rights reserved.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64711
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Shen, Xing,Xing, Shuang,Zhang, Lu,et al. Vibsanin A sensitizes human acute myeloid leukemia cells to tyrosine kinase inhibitor-induced myeloid differentiation via activation of PKC and upregulation of Lyn[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018,502(1):110-115.
APA	Shen, Xing.,Xing, Shuang.,Zhang, Lu.,Wang, Fangmin.,Ou, Hongling.,...&Yu, Zuyin.(2018).Vibsanin A sensitizes human acute myeloid leukemia cells to tyrosine kinase inhibitor-induced myeloid differentiation via activation of PKC and upregulation of Lyn.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,502(1),110-115.
MLA	Shen, Xing,et al."Vibsanin A sensitizes human acute myeloid leukemia cells to tyrosine kinase inhibitor-induced myeloid differentiation via activation of PKC and upregulation of Lyn".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 502.1(2018):110-115.