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Cage-like monoterpenoid indole alkaloids with antimicrobial activity from Alstonia scholaris
Yu, Hao-Fei; Huang, Wan-Yi; Ding, Cai-Feng; Wei, Xin; Zhang, Lan-Chun; Qin, Xu-Jie; Ma, Hong-Xia; Yang, Zi-Feng; Liu, Ya-Ping; Zhang, Rong-Ping; Wang, Xin-Hua; Luo, Xiao-Dong
Corresponding AuthorZhang, Rong-Ping(zhrpkm@163.com) ; Wang, Xin-Hua(xinhuaw@gzhmu.edu.cn) ; Luo, Xiao-Dong(xdluo@mail.kib.ac.cn)
2018
Source PublicationTETRAHEDRON LETTERS
ISSN0040-4039
Volume59Issue:31Pages:2975-2978
AbstractThree new cage-like monoterpenoid indole alkaloids, scholarisines T-V (1-3), together with three known analogues 4-6 were isolated from the leaves of Alstonia scholaris. Among them, 2 represents a unique degraded derivative, whereas 3 shares a rare 5,16-seco lactone scaffold. The structures were mainly established by extensive spectroscopic data analyses, and their plausible biosynthesis pathway from picrinine were proposed. Compared with positive control cefotaxime, alkaloid 2 showed remarkable antibacterial activity against Bacillus subtilis with an MIC value of 3.12 mu g/mL, whereas 1-3 exhibited significant antibacterial effects on Escherichia coli with an MIC value of 0.78 mu g/mL. (C) 2018 Published by Elsevier Ltd.
KeywordAlstonia scholaris lndole alkaloids Scholarisine Antimicrobial activities
DOI10.1016/j.tetlet.2018.06.047
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000439674500005
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/64699
Collection中国科学院昆明植物研究所
Recommended Citation
GB/T 7714
Yu, Hao-Fei,Huang, Wan-Yi,Ding, Cai-Feng,et al. Cage-like monoterpenoid indole alkaloids with antimicrobial activity from Alstonia scholaris[J]. TETRAHEDRON LETTERS,2018,59(31):2975-2978.
APA Yu, Hao-Fei.,Huang, Wan-Yi.,Ding, Cai-Feng.,Wei, Xin.,Zhang, Lan-Chun.,...&Luo, Xiao-Dong.(2018).Cage-like monoterpenoid indole alkaloids with antimicrobial activity from Alstonia scholaris.TETRAHEDRON LETTERS,59(31),2975-2978.
MLA Yu, Hao-Fei,et al."Cage-like monoterpenoid indole alkaloids with antimicrobial activity from Alstonia scholaris".TETRAHEDRON LETTERS 59.31(2018):2975-2978.
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