New phenoxazinone-related alkaloids from strain Streptomyces sp KIB-H1318

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	New phenoxazinone-related alkaloids from strain Streptomyces sp KIB-H1318
	Yang, Feng-Xian; Hou, Guan-Xiong; Luo, Jianying; Yang, Jing; Yan, Yijun; Huang, Sheng-Xiong
	2018
发表期刊	JOURNAL OF ANTIBIOTICS
ISSN	0021-8820
卷号	71 期号:12 页码:1040-1043
摘要	Chemical investigation of a strain Streptomyces sp. KIB-H1318 isolated from soil sample led to the discovery of three new phenoxazinone-related alkaloids 1-3, as well as two known analogs exfoliazone (4) and viridobrunnine A (5). Their structures were determined on the basis of extensive spectroscopic analysis. The antimicrobial activity and cytotoxicity of the isolates were assayed. Exfoliazone and viridobrunnine A exhibited minor antibacterial activity against Escherichia coli ATCC 8099, Bacillus subtilis ATCC 6633, and Staphylococcus aureus ATCC 6538. Compound 2 exhibited low cytotoxicity against two human cancer cell lines HeLa and SW480 with the IC50 values of 36.8 and 37.8 mu M, respectively.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64674
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Yang, Feng-Xian,Hou, Guan-Xiong,Luo, Jianying,et al. New phenoxazinone-related alkaloids from strain Streptomyces sp KIB-H1318[J]. JOURNAL OF ANTIBIOTICS,2018,71(12):1040-1043.
APA	Yang, Feng-Xian,Hou, Guan-Xiong,Luo, Jianying,Yang, Jing,Yan, Yijun,&Huang, Sheng-Xiong.(2018).New phenoxazinone-related alkaloids from strain Streptomyces sp KIB-H1318.JOURNAL OF ANTIBIOTICS,71(12),1040-1043.
MLA	Yang, Feng-Xian,et al."New phenoxazinone-related alkaloids from strain Streptomyces sp KIB-H1318".JOURNAL OF ANTIBIOTICS 71.12(2018):1040-1043.