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The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING
Li, Senlin1,2; Hong, Ze1; Wang, Zhe1,3; Li, Fei3; Mei, Jiahao1; Huang, Lulu2; Lou, Xiwen4; Zhao, Simeng3; Song, Lihua1; Chen, Wei2; Wang, Qiang2; Liu, Heng2; Cai, Yanni2; Yu, Huansha2; Xu, Huimin3; Zeng, Guangzhi3; Wang, Quanyi1; Zhu, Juanjuan1; Liu, Xing4; Tan, Ninghua1,3; Wang, Chen1,2
Corresponding AuthorLiu, Xing(xingliu@ips.ac.cn) ; Tan, Ninghua(nhtan@cpu.edu.cn) ; Wang, Chen(cwang1971@cpu.edu.cn)
2018-12-18
Source PublicationCELL REPORTS
ISSN2211-1247
Volume25Issue:12Pages:3405-+
AbstractcGAS-STING signaling is essential for innate immunity. Its misregulation promotes cancer or autoimmune and autoinflammatory diseases, and it is imperative to identify effective lead compounds that specifically downregulate the pathway. We report here that astin C, a cyclopeptide isolated from the medicinal plant Aster tataricus, inhibits cGAS-STING signaling and the innate inflammatory responses triggered by cytosolic DNAs. Moreover, mice treated with astin C are more susceptible to HSV-1 infection. Consistently, astin C markedly attenuates the autoinflammatory responses in Trex1(-/-) BMDM cells and in Trex1(-/-) mouse autoimmune disease model. Mechanistically, astin C specifically blocks the recruitment of IRF3 onto the STING signalosome. Collectively, this study characterizes a STING-specific small-molecular inhibitor that may be applied for potentially manipulating the STING-mediated clinical diseases.
DOI10.1016/j.celrep.2018.11.097
Indexed BySCI
Language英语
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000453826600015
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/64662
Collection中国科学院昆明植物研究所
Corresponding AuthorLiu, Xing; Tan, Ninghua; Wang, Chen
Affiliation1.China Pharmaceut Univ, Sch Tradit Chinese Pharm, Sch Life Sci & Technol, State Key Lab Nat Med, 639 Longmian Ave, Nanjing 211198, Jiangsu, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol,Innovat Ctr Cell Signalin, Shanghai 200031, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
4.Chinese Acad Sci, Inst Pasteur Shanghai, Key Lab Mol Virol & Immunol, Shanghai 200031, Peoples R China
Recommended Citation
GB/T 7714
Li, Senlin,Hong, Ze,Wang, Zhe,et al. The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING[J]. CELL REPORTS,2018,25(12):3405-+.
APA Li, Senlin.,Hong, Ze.,Wang, Zhe.,Li, Fei.,Mei, Jiahao.,...&Wang, Chen.(2018).The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING.CELL REPORTS,25(12),3405-+.
MLA Li, Senlin,et al."The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING".CELL REPORTS 25.12(2018):3405-+.
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