The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING

doi:10.1016/j.celrep.2018.11.097

KIB OpenIR

	The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING
	Li, Senlin 1,2; Hong, Ze 1; Wang, Zhe1,3 ; Li, Fei 3; Mei, Jiahao 1; Huang, Lulu2 ; Lou, Xiwen 4; Zhao, Simeng 3; Song, Lihua 1; Chen, Wei 2; Wang, Qiang 2; Liu, Heng 2; Cai, Yanni 2; Yu, Huansha 2; Xu, Huimin 3; Zeng, Guangzhi 3; Wang, Quanyi 1; Zhu, Juanjuan 1; Liu, Xing 4; Tan, Ninghua 1,3; Wang, Chen1,2
通讯作者	Liu, Xing(xingliu@ips.ac.cn) ; Tan, Ninghua(nhtan@cpu.edu.cn) ; Wang, Chen(cwang1971@cpu.edu.cn)
	2018-12-18
发表期刊	CELL REPORTS
ISSN	2211-1247
卷号	25 期号:12 页码:3405-+
摘要	cGAS-STING signaling is essential for innate immunity. Its misregulation promotes cancer or autoimmune and autoinflammatory diseases, and it is imperative to identify effective lead compounds that specifically downregulate the pathway. We report here that astin C, a cyclopeptide isolated from the medicinal plant Aster tataricus, inhibits cGAS-STING signaling and the innate inflammatory responses triggered by cytosolic DNAs. Moreover, mice treated with astin C are more susceptible to HSV-1 infection. Consistently, astin C markedly attenuates the autoinflammatory responses in Trex1(-/-) BMDM cells and in Trex1(-/-) mouse autoimmune disease model. Mechanistically, astin C specifically blocks the recruitment of IRF3 onto the STING signalosome. Collectively, this study characterizes a STING-specific small-molecular inhibitor that may be applied for potentially manipulating the STING-mediated clinical diseases.
DOI	10.1016/j.celrep.2018.11.097
收录类别	SCI
语种	英语
WOS记录号	WOS:000453826600015
引用统计	被引频次：111[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64662
专题	中国科学院昆明植物研究所
通讯作者	Liu, Xing; Tan, Ninghua; Wang, Chen
作者单位	1.China Pharmaceut Univ, Sch Tradit Chinese Pharm, Sch Life Sci & Technol, State Key Lab Nat Med, 639 Longmian Ave, Nanjing 211198, Jiangsu, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol,Innovat Ctr Cell Signalin, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Chinese Acad Sci, Inst Pasteur Shanghai, Key Lab Mol Virol & Immunol, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Li, Senlin,Hong, Ze,Wang, Zhe,et al. The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING[J]. CELL REPORTS,2018,25(12):3405-+.
APA	Li, Senlin.,Hong, Ze.,Wang, Zhe.,Li, Fei.,Mei, Jiahao.,...&Wang, Chen.(2018).The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING.CELL REPORTS,25(12),3405-+.
MLA	Li, Senlin,et al."The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING".CELL REPORTS 25.12(2018):3405-+.