Phenolic compounds from the insect Blaps japanensis with inhibitory activities towards cancer cells, COX-2, ROCK1 and JAK3

	Phenolic compounds from the insect Blaps japanensis with inhibitory activities towards cancer cells, COX-2, ROCK1 and JAK3
	Yan, Yong-Ming 1,2; Zhu, Hong-Jie 1; Zhou, Feng-Jiao 1; Tu, Zheng-Chao 3,4; Cheng, Yong-Xian 2
	2019-02-22
发表期刊	TETRAHEDRON
ISSN	0040-4020
卷号	75 期号:8 页码:1029-1033
摘要	The insect Blaps japanensis have been used as an ethnomedicine in China for the treatment of several disorders such as cancer and inflammation. Our investigation with this insect led to the isolation of eight new and two known phenolic compounds. The structures of the new compounds, blapsins C-J (1-8), were identified by spectroscopic data. The inhibitory activities of all the compounds except of 9 against human cancer cells (A549, K562 and Huh-7), COX-2, ROCK1, and JAK3 were evaluated. Several compounds were found to be biologically active in these assays. (C) 2018 Published by Elsevier Ltd.
关键词	Insect Blaps japanensis Phenolic compounds Cytotoxicity COX-2 ROCK1 JAK3
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64614
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Tu, Zheng-Chao; Cheng, Yong-Xian
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China 2.Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Shenzhen 518060, Peoples R China 3.Jinan Univ, Sch Pharm, Guangzhou 510632, Guangdong, Peoples R China 4.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Yan, Yong-Ming,Zhu, Hong-Jie,Zhou, Feng-Jiao,et al. Phenolic compounds from the insect Blaps japanensis with inhibitory activities towards cancer cells, COX-2, ROCK1 and JAK3[J]. TETRAHEDRON,2019,75(8):1029-1033.
APA	Yan, Yong-Ming,Zhu, Hong-Jie,Zhou, Feng-Jiao,Tu, Zheng-Chao,&Cheng, Yong-Xian.(2019).Phenolic compounds from the insect Blaps japanensis with inhibitory activities towards cancer cells, COX-2, ROCK1 and JAK3.TETRAHEDRON,75(8),1029-1033.
MLA	Yan, Yong-Ming,et al."Phenolic compounds from the insect Blaps japanensis with inhibitory activities towards cancer cells, COX-2, ROCK1 and JAK3".TETRAHEDRON 75.8(2019):1029-1033.

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