Cytotoxic Effects of Compounds Isolated from Ricinodendron heudelotii

	Cytotoxic Effects of Compounds Isolated from Ricinodendron heudelotii
	Yakubu, Omolara F.1,2; Adebayo, Abiodun H.1; Dokunmu, Titilope M.1; Zhang, Ying-Jun2 ; Iweala, Emeka E. J.1
	2019
发表期刊	MOLECULES
ISSN	1420-3049
卷号	24 期号:1 页码:11
摘要	This study was designed to explore the in vitro anticancer effects of the bioactive compounds isolated from Ricinodendron heudelotii on selected cancer cell lines. The leaves of the plant were extracted with ethanol and partitioned in sequence with petroleum ether, ethyl acetate, and n-butanol. The ethyl acetate fraction was phytochemically studied using thin layer chromatography (TLC) and column chromatography (CC). Structural elucidation of pure compounds obtained from the ethyl acetate fraction was done using mass spectra, H-1-NMR, and C-13-NMR analysis. The isolated compounds were subsequently screened using five different cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7, SW-480, and normal lung epithelial cell line, BEAS-2B, to assess their cytotoxic effects. Nine compounds were isolated and structurally elucidated as gallic acid, gallic acid ethyl ester, corilagin, quercetin-3-O-rhamnoside, myricetin-3-O-rhamnoside, 1,4,6-tri-O-galloyl glucose, 3,4,6-tri-O-galloyl glucose, 1,2,6-tri-O-galloyl glucose, and 4,6-di-O-galloyl glucose. Corilagin exhibited the most cytotoxic activity with an IC50 value of 33.18 g/mL against MCF-7 cells, which were comparable to cisplatin with an IC50 value of 27.43 mu g/mL. The result suggests that corilagin isolated from R. heudelotii has the potential to be developed as an effective therapeutic agent against the growth of breast cancer cells.
关键词	anticancer Ricinodendron heudelotii chemoprevention
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64411
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Adebayo, Abiodun H.; Zhang, Ying-Jun
作者单位	1.Covenant Univ, Coll Sci & Technol, Dept Biochem, PMB 1023, Ota, Ogun State, Nigeria 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Yakubu, Omolara F.,Adebayo, Abiodun H.,Dokunmu, Titilope M.,et al. Cytotoxic Effects of Compounds Isolated from Ricinodendron heudelotii[J]. MOLECULES,2019,24(1):11.
APA	Yakubu, Omolara F.,Adebayo, Abiodun H.,Dokunmu, Titilope M.,Zhang, Ying-Jun,&Iweala, Emeka E. J..(2019).Cytotoxic Effects of Compounds Isolated from Ricinodendron heudelotii.MOLECULES,24(1),11.
MLA	Yakubu, Omolara F.,et al."Cytotoxic Effects of Compounds Isolated from Ricinodendron heudelotii".MOLECULES 24.1(2019):11.

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