| Chepraecoxins A-G, ent-Kaurane Diterpenoids with alpha-Glucosidase Inhibitory Activities from Chelonopsis praecox | |
Deng, Zhen-Tao1,2,4; Geng, Chang-An1,2 ; Yang, Tong-Hua1,2; Xiang, Chun-Lei3; Chen, Ji-Jun1,2,4
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| 2019 | |
| Source Publication | FITOTERAPIA
 |
| ISSN | 0367-326X |
| Volume | 132Pages:60-67 |
| Abstract | Our random bioassay revealed that the CHCl3 part of Chelonopsis praecox (Lamiaceae) showed significant activity against alpha-glucosidase with the inhibitory rate of 99.6 +/- 0.4 % (330 mu g/mL). Bioassay-guided isolation yielded seven new ent-kaurane diterpenoids, chepraecoxins A-G (1-7), and three known ones (8-10), driven by LC-MS analyses. The structures of chepraecoxins A-G (1-7) were elucidated by X-ray crystallographic and extensive spectroscopic analyses. Compounds 1, 6, and 10 showed obvious alpha-glucosidase inhibitory effects with IC50 values of 305.0, 361.0 and 174.5 mu M, respectively. Enzyme kinetics study suggested that compound 1 inhibited the alpha-glucosidase by a noncompetitive type mechanism (K-i = 354.4 mu M). |
| Keyword | Chelonopsis praecox chepraecoxins A-G ent-kaurane diterpenoids alpha-glucosidase |
| Indexed By | SCI |
| Language | 英语 |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/64398 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 中国科学院东亚植物多样性与生物地理学重点实验室 |
| Corresponding Author | Chen, Ji-Jun |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Key Lab Plant Divers & Biogeog East Asia, Kunming 650201, Yunnan, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Deng, Zhen-Tao,Geng, Chang-An,Yang, Tong-Hua,et al. Chepraecoxins A-G, ent-Kaurane Diterpenoids with alpha-Glucosidase Inhibitory Activities from Chelonopsis praecox[J]. FITOTERAPIA,2019,132:60-67. |
| APA | Deng, Zhen-Tao,Geng, Chang-An,Yang, Tong-Hua,Xiang, Chun-Lei,&Chen, Ji-Jun.(2019).Chepraecoxins A-G, ent-Kaurane Diterpenoids with alpha-Glucosidase Inhibitory Activities from Chelonopsis praecox.FITOTERAPIA,132,60-67. |
| MLA | Deng, Zhen-Tao,et al."Chepraecoxins A-G, ent-Kaurane Diterpenoids with alpha-Glucosidase Inhibitory Activities from Chelonopsis praecox".FITOTERAPIA 132(2019):60-67. |
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| Deng-2019-Chepraecox（1349KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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