Chepraecoxins A-G, ent-Kaurane Diterpenoids with alpha-Glucosidase Inhibitory Activities from Chelonopsis praecox

	Chepraecoxins A-G, ent-Kaurane Diterpenoids with alpha-Glucosidase Inhibitory Activities from Chelonopsis praecox
	Deng, Zhen-Tao 1,2,4; Geng, Chang-An1,2 ; Yang, Tong-Hua 1,2; Xiang, Chun-Lei3 ; Chen, Ji-Jun1,2,4
	2019
发表期刊	FITOTERAPIA
ISSN	0367-326X
卷号	132 页码:60-67
摘要	Our random bioassay revealed that the CHCl3 part of Chelonopsis praecox (Lamiaceae) showed significant activity against alpha-glucosidase with the inhibitory rate of 99.6 +/- 0.4 % (330 mu g/mL). Bioassay-guided isolation yielded seven new ent-kaurane diterpenoids, chepraecoxins A-G (1-7), and three known ones (8-10), driven by LC-MS analyses. The structures of chepraecoxins A-G (1-7) were elucidated by X-ray crystallographic and extensive spectroscopic analyses. Compounds 1, 6, and 10 showed obvious alpha-glucosidase inhibitory effects with IC50 values of 305.0, 361.0 and 174.5 mu M, respectively. Enzyme kinetics study suggested that compound 1 inhibited the alpha-glucosidase by a noncompetitive type mechanism (K-i = 354.4 mu M).
关键词	Chelonopsis praecox chepraecoxins A-G ent-kaurane diterpenoids alpha-glucosidase
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64398
专题	植物化学与西部植物资源持续利用国家重点实验室中国科学院东亚植物多样性与生物地理学重点实验室
通讯作者	Chen, Ji-Jun
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Key Lab Plant Divers & Biogeog East Asia, Kunming 650201, Yunnan, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Deng, Zhen-Tao,Geng, Chang-An,Yang, Tong-Hua,et al. Chepraecoxins A-G, ent-Kaurane Diterpenoids with alpha-Glucosidase Inhibitory Activities from Chelonopsis praecox[J]. FITOTERAPIA,2019,132:60-67.
APA	Deng, Zhen-Tao,Geng, Chang-An,Yang, Tong-Hua,Xiang, Chun-Lei,&Chen, Ji-Jun.(2019).Chepraecoxins A-G, ent-Kaurane Diterpenoids with alpha-Glucosidase Inhibitory Activities from Chelonopsis praecox.FITOTERAPIA,132,60-67.
MLA	Deng, Zhen-Tao,et al."Chepraecoxins A-G, ent-Kaurane Diterpenoids with alpha-Glucosidase Inhibitory Activities from Chelonopsis praecox".FITOTERAPIA 132(2019):60-67.

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