Chepraecoxins A-G, ent-Kaurane Diterpenoids with alpha-Glucosidase Inhibitory Activities from Chelonopsis praecox
Deng, Zhen-Tao1,2,4; Geng, Chang-An1,2; Yang, Tong-Hua1,2; Xiang, Chun-Lei3; Chen, Ji-Jun1,2,4
2019
Source PublicationFITOTERAPIA
ISSN0367-326X
Volume132Pages:60-67
AbstractOur random bioassay revealed that the CHCl3 part of Chelonopsis praecox (Lamiaceae) showed significant activity against alpha-glucosidase with the inhibitory rate of 99.6 +/- 0.4 % (330 mu g/mL). Bioassay-guided isolation yielded seven new ent-kaurane diterpenoids, chepraecoxins A-G (1-7), and three known ones (8-10), driven by LC-MS analyses. The structures of chepraecoxins A-G (1-7) were elucidated by X-ray crystallographic and extensive spectroscopic analyses. Compounds 1, 6, and 10 showed obvious alpha-glucosidase inhibitory effects with IC50 values of 305.0, 361.0 and 174.5 mu M, respectively. Enzyme kinetics study suggested that compound 1 inhibited the alpha-glucosidase by a noncompetitive type mechanism (K-i = 354.4 mu M).
KeywordChelonopsis praecox chepraecoxins A-G ent-kaurane diterpenoids alpha-glucosidase
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/64398
Collection植物化学与西部植物资源持续利用国家重点实验室
中国科学院东亚植物多样性与生物地理学重点实验室
Corresponding AuthorChen, Ji-Jun
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Key Lab Plant Divers & Biogeog East Asia, Kunming 650201, Yunnan, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Deng, Zhen-Tao,Geng, Chang-An,Yang, Tong-Hua,et al. Chepraecoxins A-G, ent-Kaurane Diterpenoids with alpha-Glucosidase Inhibitory Activities from Chelonopsis praecox[J]. FITOTERAPIA,2019,132:60-67.
APA Deng, Zhen-Tao,Geng, Chang-An,Yang, Tong-Hua,Xiang, Chun-Lei,&Chen, Ji-Jun.(2019).Chepraecoxins A-G, ent-Kaurane Diterpenoids with alpha-Glucosidase Inhibitory Activities from Chelonopsis praecox.FITOTERAPIA,132,60-67.
MLA Deng, Zhen-Tao,et al."Chepraecoxins A-G, ent-Kaurane Diterpenoids with alpha-Glucosidase Inhibitory Activities from Chelonopsis praecox".FITOTERAPIA 132(2019):60-67.
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