| Renoprotective meroterpenoids from the fungus Ganoderma cochlear | |
| Wang, Xin-Long2; Wu, Ze-Hong1; Di, Lei2; Zhou, Feng-Jiao2; Yan, Yong-Ming1; Cheng, Yong-Xian1 | |
| 2019 | |
| 发表期刊 | FITOTERAPIA
 |
| ISSN | 0367-326X |
| 卷号 | 132页码:88-93 |
| 摘要 | Nine multifarious new meroterpenoids, cochlearols E-M (1-9), along with seven known meroterpenoids 10-16, were isolated from the fruiting bodies of Ganoderma cochlear. Racemic 1, 6-8, 10 and 13 were separated by chiral HPLC. The structures were elucidated based on detailed spectroscopic analyses (HRESIMS, 1D/2D-NMR) and calculated electronic circular dichroism (ECD). Their biological activities against renal fibrosis were evaluated by using rat normal and diseased renal interstitial fibroblast cells (NRK-49F). The results show that compounds 7a, 7b, and 10a exhibit potent proliferation inhibition in TGF-beta 1-induced NRK-49F cells. |
| 关键词 | Ganoderma cochlear Meroterpenoids ECD calculations Renal fibrosis |
| 收录类别 | SCI |
| 语种 | 英语 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/64386 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Cheng, Yong-Xian |
| 作者单位 | 1.Shenzhen Univ, Hlth Sci Ctr, Sch Med, Guangdong Key Lab Genome Stabil & Dis Prevent,Sch, Shenzhen 518060, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xin-Long,Wu, Ze-Hong,Di, Lei,et al. Renoprotective meroterpenoids from the fungus Ganoderma cochlear[J]. FITOTERAPIA,2019,132:88-93. |
| APA | Wang, Xin-Long,Wu, Ze-Hong,Di, Lei,Zhou, Feng-Jiao,Yan, Yong-Ming,&Cheng, Yong-Xian.(2019).Renoprotective meroterpenoids from the fungus Ganoderma cochlear.FITOTERAPIA,132,88-93. |
| MLA | Wang, Xin-Long,et al."Renoprotective meroterpenoids from the fungus Ganoderma cochlear".FITOTERAPIA 132(2019):88-93. |
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| Wang-2019-Renoprotec（827KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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