Renoprotective meroterpenoids from the fungus Ganoderma cochlear
Wang, Xin-Long2; Wu, Ze-Hong1; Di, Lei2; Zhou, Feng-Jiao2; Yan, Yong-Ming1; Cheng, Yong-Xian1
Source PublicationFITOTERAPIA
AbstractNine multifarious new meroterpenoids, cochlearols E-M (1-9), along with seven known meroterpenoids 10-16, were isolated from the fruiting bodies of Ganoderma cochlear. Racemic 1, 6-8, 10 and 13 were separated by chiral HPLC. The structures were elucidated based on detailed spectroscopic analyses (HRESIMS, 1D/2D-NMR) and calculated electronic circular dichroism (ECD). Their biological activities against renal fibrosis were evaluated by using rat normal and diseased renal interstitial fibroblast cells (NRK-49F). The results show that compounds 7a, 7b, and 10a exhibit potent proliferation inhibition in TGF-beta 1-induced NRK-49F cells.
KeywordGanoderma cochlear Meroterpenoids ECD calculations Renal fibrosis
Indexed BySCI
Document Type期刊论文
Corresponding AuthorCheng, Yong-Xian
Affiliation1.Shenzhen Univ, Hlth Sci Ctr, Sch Med, Guangdong Key Lab Genome Stabil & Dis Prevent,Sch, Shenzhen 518060, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Wang, Xin-Long,Wu, Ze-Hong,Di, Lei,et al. Renoprotective meroterpenoids from the fungus Ganoderma cochlear[J]. FITOTERAPIA,2019,132:88-93.
APA Wang, Xin-Long,Wu, Ze-Hong,Di, Lei,Zhou, Feng-Jiao,Yan, Yong-Ming,&Cheng, Yong-Xian.(2019).Renoprotective meroterpenoids from the fungus Ganoderma cochlear.FITOTERAPIA,132,88-93.
MLA Wang, Xin-Long,et al."Renoprotective meroterpenoids from the fungus Ganoderma cochlear".FITOTERAPIA 132(2019):88-93.
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