Enantioselective N-Heterocyclic Carbene-Catalyzed Synthesis of Spirocyclic Oxindole-benzofuroazepinones

	Enantioselective N-Heterocyclic Carbene-Catalyzed Synthesis of Spirocyclic Oxindole-benzofuroazepinones
	Gao, Zhong-Hua 1; Chen, Kun-Quan 1; Zhang, Yan 1; Kong, Ling-Mei 2; Li, Yan2,3 ; Ye, Song 1,3
	2018-12-21
发表期刊	JOURNAL OF ORGANIC CHEMISTRY
ISSN	0022-3263
卷号	83 期号:24 页码:15225-15235
摘要	Herein, we report an enantioselective synthesis of azepinones via the N-heterocyclic carbene (NHC) catalyzed [3+4] annulation reaction of isatin-derived enals and aurone-derived azadienes. The corresponding spirocyclic oxindole-benzofuroazepinones were obtained in good yields, with excellent diastereo- and enantioselectivities. The resulted azepinones were evaluated for their in vitro cytotoxic activities against six human tumor cell lines, with two compounds showing significant inhibitory activity comparable with that of cisplatin.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64351
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Li, Yan; Ye, Song
作者单位	1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Gao, Zhong-Hua,Chen, Kun-Quan,Zhang, Yan,et al. Enantioselective N-Heterocyclic Carbene-Catalyzed Synthesis of Spirocyclic Oxindole-benzofuroazepinones[J]. JOURNAL OF ORGANIC CHEMISTRY,2018,83(24):15225-15235.
APA	Gao, Zhong-Hua,Chen, Kun-Quan,Zhang, Yan,Kong, Ling-Mei,Li, Yan,&Ye, Song.(2018).Enantioselective N-Heterocyclic Carbene-Catalyzed Synthesis of Spirocyclic Oxindole-benzofuroazepinones.JOURNAL OF ORGANIC CHEMISTRY,83(24),15225-15235.
MLA	Gao, Zhong-Hua,et al."Enantioselective N-Heterocyclic Carbene-Catalyzed Synthesis of Spirocyclic Oxindole-benzofuroazepinones".JOURNAL OF ORGANIC CHEMISTRY 83.24(2018):15225-15235.