Enantioselective N-Heterocyclic Carbene-Catalyzed Synthesis of Spirocyclic Oxindole-benzofuroazepinones
Gao, Zhong-Hua1; Chen, Kun-Quan1; Zhang, Yan1; Kong, Ling-Mei2; Li, Yan2,3; Ye, Song1,3
2018-12-21
Source PublicationJOURNAL OF ORGANIC CHEMISTRY
ISSN0022-3263
Volume83Issue:24Pages:15225-15235
AbstractHerein, we report an enantioselective synthesis of azepinones via the N-heterocyclic carbene (NHC) catalyzed [3+4] annulation reaction of isatin-derived enals and aurone-derived azadienes. The corresponding spirocyclic oxindole-benzofuroazepinones were obtained in good yields, with excellent diastereo- and enantioselectivities. The resulted azepinones were evaluated for their in vitro cytotoxic activities against six human tumor cell lines, with two compounds showing significant inhibitory activity comparable with that of cisplatin.
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/64351
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLi, Yan; Ye, Song
Affiliation1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Gao, Zhong-Hua,Chen, Kun-Quan,Zhang, Yan,et al. Enantioselective N-Heterocyclic Carbene-Catalyzed Synthesis of Spirocyclic Oxindole-benzofuroazepinones[J]. JOURNAL OF ORGANIC CHEMISTRY,2018,83(24):15225-15235.
APA Gao, Zhong-Hua,Chen, Kun-Quan,Zhang, Yan,Kong, Ling-Mei,Li, Yan,&Ye, Song.(2018).Enantioselective N-Heterocyclic Carbene-Catalyzed Synthesis of Spirocyclic Oxindole-benzofuroazepinones.JOURNAL OF ORGANIC CHEMISTRY,83(24),15225-15235.
MLA Gao, Zhong-Hua,et al."Enantioselective N-Heterocyclic Carbene-Catalyzed Synthesis of Spirocyclic Oxindole-benzofuroazepinones".JOURNAL OF ORGANIC CHEMISTRY 83.24(2018):15225-15235.
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