Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum
Feng, Ling1,2,3,4; Zhang, Yu1,3; Liu, Yan-Chun1,3; Liu, Yan1,3; Luo, Shi-Hong1,3; Huang, Chun-Shuai1,3; Li, Sheng-Hong1,3
2019-01-15
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY
ISSN0968-0896
Volume27Issue:2Pages:442-446
AbstractA new flavoalkaloid racemate, leucoflavonine (1), together with its flavonoid precursor pectolinarigenin (2), was isolated from the leaves of Leucosceptrum canum collected from Tibet. Its structure was established by comprehensive spectroscopic analysis. Chrial separation of the enantiomers of 1 was achieved, and their absolute configurations were determined as S-(+)- and R-(-)-leucoflavonines ((+)-1a and (-)-1b) by comparison of their computational and experimental optical rotations. Biological assays indicated that both (+)-1a and (-)-1b exhibited inhibitory activity against acetylchlorinesterase (AChE) in vitro (IC50 = 68.0 +/- 8.6 and 18.3 +/- 1.8 mu M, respectively). Moreover, (-)-1b displayed cytotoxicity against human hepatoma cells HepG2 (IC50 = 52.9 +/- 3.6 mu M), and inhibited the production of interleukelin-2 (IL-2) in Jurkat cells (IC50 = 16.5 +/- 0.9 mu M), while (+)-1a showed no obvious activity in these assays.
KeywordLeucosceptrum canum Lamiaceae Flavoalkaloid Leucoflavonine Biological activities
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/64251
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLi, Sheng-Hong
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Southwest Forestry Univ, Forestry Sch, Kunming 655024, Yunnan, Peoples R China
3.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Feng, Ling,Zhang, Yu,Liu, Yan-Chun,et al. Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2019,27(2):442-446.
APA Feng, Ling.,Zhang, Yu.,Liu, Yan-Chun.,Liu, Yan.,Luo, Shi-Hong.,...&Li, Sheng-Hong.(2019).Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum.BIOORGANIC & MEDICINAL CHEMISTRY,27(2),442-446.
MLA Feng, Ling,et al."Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum".BIOORGANIC & MEDICINAL CHEMISTRY 27.2(2019):442-446.
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