| Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum | |
Feng, Ling1,2,3,4; Zhang, Yu1,3 ; Liu, Yan-Chun1,3; Liu, Yan1,3; Luo, Shi-Hong1,3; Huang, Chun-Shuai1,3; Li, Sheng-Hong1,3
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| 2019-01-15 | |
| 发表期刊 | BIOORGANIC & MEDICINAL CHEMISTRY
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| ISSN | 0968-0896 |
| 卷号 | 27期号:2页码:442-446 |
| 摘要 | A new flavoalkaloid racemate, leucoflavonine (1), together with its flavonoid precursor pectolinarigenin (2), was isolated from the leaves of Leucosceptrum canum collected from Tibet. Its structure was established by comprehensive spectroscopic analysis. Chrial separation of the enantiomers of 1 was achieved, and their absolute configurations were determined as S-(+)- and R-(-)-leucoflavonines ((+)-1a and (-)-1b) by comparison of their computational and experimental optical rotations. Biological assays indicated that both (+)-1a and (-)-1b exhibited inhibitory activity against acetylchlorinesterase (AChE) in vitro (IC50 = 68.0 +/- 8.6 and 18.3 +/- 1.8 mu M, respectively). Moreover, (-)-1b displayed cytotoxicity against human hepatoma cells HepG2 (IC50 = 52.9 +/- 3.6 mu M), and inhibited the production of interleukelin-2 (IL-2) in Jurkat cells (IC50 = 16.5 +/- 0.9 mu M), while (+)-1a showed no obvious activity in these assays. |
| 关键词 | Leucosceptrum canum Lamiaceae Flavoalkaloid Leucoflavonine Biological activities |
| 收录类别 | SCI |
| 语种 | 英语 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/64251 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Li, Sheng-Hong |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Southwest Forestry Univ, Forestry Sch, Kunming 655024, Yunnan, Peoples R China 3.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Ling,Zhang, Yu,Liu, Yan-Chun,et al. Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2019,27(2):442-446. |
| APA | Feng, Ling.,Zhang, Yu.,Liu, Yan-Chun.,Liu, Yan.,Luo, Shi-Hong.,...&Li, Sheng-Hong.(2019).Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum.BIOORGANIC & MEDICINAL CHEMISTRY,27(2),442-446. |
| MLA | Feng, Ling,et al."Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum".BIOORGANIC & MEDICINAL CHEMISTRY 27.2(2019):442-446. |
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