COX-2 and JAK3 inhibitory meroterpenoids from the mushroom Ganoderma theaecolum

doi:10.1016/j.tet.2018.06.053

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	COX-2 and JAK3 inhibitory meroterpenoids from the mushroom Ganoderma theaecolum
	Luo, Qi; Li, Min-Ke; Luo, Jing-Feng; Tu, Zheng-Chao; Cheng, Yong-Xian
通讯作者	Tu, Zheng-Chao(tu_zhengchao@gibh.ac.cn) ; Cheng, Yong-Xian(yxcheng@szu.edu.cn)
	2018
发表期刊	TETRAHEDRON
ISSN	0040-4020
卷号	74 期号:31 页码:4288-4288
摘要	Ganoderma mushrooms possess antioxidant, anticancer, and immunomodulatory properties. In this study, eleven new meroterpenoids, ganotheaecolumols A-K (1-6,10,11,13,14, and 17), together with nine known ones (7-9,12,15,16, and 18-20) were isolated from the fruiting bodies of G. theaecolum. Their structures were elucidated by spectroscopic and computational methods. All the new compounds and iso-ganotheaecolumol I (12) were tested for their inhibitory activities against COX-2 and JAK3 kinases, and cytotoxic effects. It was found that most meroterpenoids could inhibit COX-2 and JAK3 with compounds 3,4,12,13, and 17 having IC50 values of 1.05 +/- 0.10,1.38 +/- 0.11, 2.61 +/- 0.79, 3.47 +/- 0.58, and 4.84 +/- 0.60 mu M towards COX-2. Whereas, none of the test compounds exhibited cytotoxic effects against human cancer cells (K562, A549, and Huh-7). (C) 2018 Published by Elsevier Ltd.
关键词	Ganoderma theaecolum Meroterpenoids Ganotheaecolumols A-K COX-2 JAK3
DOI	10.1016/j.tet.2018.06.053
收录类别	SCI ; SCI
语种	英语
WOS记录号	WOS:000439403400015
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/63315
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Luo, Qi,Li, Min-Ke,Luo, Jing-Feng,et al. COX-2 and JAK3 inhibitory meroterpenoids from the mushroom Ganoderma theaecolum[J]. TETRAHEDRON,2018,74(31):4288-4288.
APA	Luo, Qi,Li, Min-Ke,Luo, Jing-Feng,Tu, Zheng-Chao,&Cheng, Yong-Xian.(2018).COX-2 and JAK3 inhibitory meroterpenoids from the mushroom Ganoderma theaecolum.TETRAHEDRON,74(31),4288-4288.
MLA	Luo, Qi,et al."COX-2 and JAK3 inhibitory meroterpenoids from the mushroom Ganoderma theaecolum".TETRAHEDRON 74.31(2018):4288-4288.

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